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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Fig. 5

Alleviation of acrolein-induced SK-N-SH cell death by DP. a, b SK-N-SH cells were exposed to different concentrations of 6-OHDA or acrolein for 4 h, which induced dose-dependent cell death, based on the MTT test. **P < 0.01, compared to control group. c DP (with a 15 min delay following 6-OHDA exposure), at various concentrations did not affect the cell viability, compared to the 6-OHDA (400 μM) exposure group. d DP at various concentrations significantly reduced the acrolein-mediated cell death. *P < 0.05, **P < 0.01, compared to the 6-OHDA (c) or acrolein only group (d). ANOVA and Tukey’s post hoc test. All data are expressed as mean ± SD, n = 4 in each group

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