Author (year) | Type of intervention | Model | Species/Strains | Route of administration | Doses per animal | Follow-up time | Outcome parameters |
---|---|---|---|---|---|---|---|
McCoy (2008) [19] | Neural induction | 6-OHDA | Rats/Sprague-Dawley | Intrastriatal | 4 × 104 | 4 weeks | Rotation (turns/20 min) Number of TH+ neurons in SNpc and striatum Microglial burden in SNpc (IOD) |
Zhou (2013) [30] | Neural induction | MPTP (hemi) | Monkeys/Rhesus | Intrastriatal | 6 × 106 | 4 months | UPDRS (scores) Rotation (turns/min) Percentage of TH+ neurons in the substantia nigra |
Park (2014) [20] | Original | 6-OHDA | Rats/Sprague-Dawley | Cisterna magna injection | 2 × 106 | 6 weeks | Rotation (turns/50 min) Relative neuronal protein expression of midbrain tissues |
Berg (2015) [24] | Original | 6-OHDA | Rats/Wistar | Intranigral | 3 × 105 | 3 weeks | 8-arm radial maze (times) Rotation (turns/min) Number of newly generated cells in the adult DG Nigral mRNA levels of GDNF, BDNF and GFAP Microglia number in the transplantation area |
Choi (2015) [23] | Original | 6-OHDA | Mice/C57BL6 | Intravenous | 1 × 106 | 6 weeks | Rotation (turns/30 min) Rotarod (s) Number of TH Neurons in the SN PET imaging analysis of dopamine D2 receptor in the striatum (binding potential) The population of damaged mitochondria (%) Mitochondrial complex I activity (%) |
Schwerk (2015) [22] | Original | 6-OHDA | Rats/Wistar | Intranigral | 3 × 105 | 6 months | Rotation (turns/min) 8-arm radial maze (times) Percentage of TH+ neurons in the SN (%) Neurogenesis of subventricular and hippocampal cells (cell number) EPO, IL-10, IL-4, and IL-2 levels (pg/ml) |
Takahashi (2017) [25] | Neural induction | 6-OHDA | Rats/Wistar | Ipsilateral MFB injection | 4 × 105 | 4 weeks | Rotation (turns/min) |
Chi (2018) [31] | Original | MPTP | Mice/C57BL6 | Intrastriatal | 1 × 106 | 3 weeks | Beam walking (s) Rotarod (s) Locomotor activity Comparable TH quantity of the SN (%) |
Meligy (2019) [28] | Original | Rotenone | Rats/Wistar | Intracardiac | 1 × 106 | 2 weeks | Rotarod (s) Activity cage (counts/5 min) Pole test (s) Pale and dark neurons in SNc (cell number) TH+ cells in the SNc (cells/mm2) Blood levels of angiopoietin-2 (ng/ml) and dopamine (pg/ml) GFAP and Nestin mRNA gene expression |
Moayeri (2020) [27] | Original | 6-HD | Rats/Sprague-Dawley | Ipsilateral MFB injection | 3 × 105 | 6 weeks | Rotation (turns/1 h) Nissl-stained cells in the SNc |