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Table 1 List of all 10 studies that met the inclusion criteria based on full-text assessment

From: Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson’s disease: a systematic review and meta-analysis

Author (year)

Type of intervention

Model

Species/Strains

Route of administration

Doses per animal

Follow-up time

Outcome parameters

McCoy (2008) [19]

Neural induction

6-OHDA

Rats/Sprague-Dawley

Intrastriatal

4 × 104

4 weeks

Rotation (turns/20 min)

Number of TH+ neurons in SNpc and striatum

Microglial burden in SNpc (IOD)

Zhou (2013) [30]

Neural induction

MPTP (hemi)

Monkeys/Rhesus

Intrastriatal

6 × 106

4 months

UPDRS (scores)

Rotation (turns/min)

Percentage of TH+ neurons in the substantia nigra

Park (2014) [20]

Original

6-OHDA

Rats/Sprague-Dawley

Cisterna magna injection

2 × 106

6 weeks

Rotation (turns/50 min)

Relative neuronal protein expression of midbrain tissues

Berg (2015) [24]

Original

6-OHDA

Rats/Wistar

Intranigral

3 × 105

3 weeks

8-arm radial maze (times)

Rotation (turns/min)

Number of newly generated cells in the adult DG

Nigral mRNA levels of GDNF, BDNF and GFAP

Microglia number in the transplantation area

Choi (2015) [23]

Original

6-OHDA

Mice/C57BL6

Intravenous

1 × 106

6 weeks

Rotation (turns/30 min)

Rotarod (s)

Number of TH Neurons in the SN

PET imaging analysis of dopamine D2 receptor in the striatum (binding potential)

The population of damaged mitochondria (%)

Mitochondrial complex I activity (%)

Schwerk (2015) [22]

Original

6-OHDA

Rats/Wistar

Intranigral

3 × 105

6 months

Rotation (turns/min)

8-arm radial maze (times)

Percentage of TH+ neurons in the SN (%)

Neurogenesis of subventricular and hippocampal cells (cell number)

EPO, IL-10, IL-4, and IL-2 levels (pg/ml)

Takahashi (2017) [25]

Neural induction

6-OHDA

Rats/Wistar

Ipsilateral MFB injection

4 × 105

4 weeks

Rotation (turns/min)

Chi (2018) [31]

Original

MPTP

Mice/C57BL6

Intrastriatal

1 × 106

3 weeks

Beam walking (s)

Rotarod (s)

Locomotor activity

Comparable TH quantity of the SN (%)

Meligy (2019) [28]

Original

Rotenone

Rats/Wistar

Intracardiac

1 × 106

2 weeks

Rotarod (s)

Activity cage (counts/5 min)

Pole test (s)

Pale and dark neurons in SNc (cell number)

TH+ cells in the SNc (cells/mm2)

Blood levels of angiopoietin-2 (ng/ml) and dopamine (pg/ml)

GFAP and Nestin mRNA gene expression

Moayeri (2020) [27]

Original

6-HD

Rats/Sprague-Dawley

Ipsilateral MFB injection

3 × 105

6 weeks

Rotation (turns/1 h)

Nissl-stained cells in the SNc

  1. Abbreviations: TH Tyrosine hydroxylase, SNc substantia nigra compacta, DG dentate gyrus, MFB medial forebrain bundle, BP n-butylidenephthalid