Table 1 Characteristics of the reviewed cross-sectional studies
No. | Author | Study population (cohort) | AT(N) Biomarkers | Biomarker method / assay | NPS instrument | NPS with association | Significant findings |
|---|---|---|---|---|---|---|---|
1 | Binette et al. 2020 [45] | 117 ADAD mutation carriers (DIAN) | A | PiB-PET, global SUVR | IPIP-NEO-120, NPI-Q | NPI-Q score | • ↑ A associated with ↑ NPI-Q score |
2 | Gatchel et al. 2017 [46] | 111 CU - 5 with depression (HABS) | A T | PiB PET, DVR cut-off > 1.20 [18F]T807-PET | GDS | GDS score | • ↑ T associated with ↑ GDS score |
3 | Kim et al. 2018 [47] | 667 CU (NACC) | A T | Pathology: neuritic plaques (T) and neurofibrillary tangles (A) | NPI-Q | Psychosis | • ↑ T associated with ↑ psychosis • No association between A and NPI-Q score |
4 | Krell-Roesch et al. 2017 [48] | 1038 CU (MCSA) | A | PiB-PET, SUVR cut-off ≥1.40 | BAI, BDI-II | Anxiety symptoms, depressive symptoms | • ↑ A associated with ↑ anxiety and ↑ depressive symptoms |
5 | Lussier et al. 2020 [49] | 96 CU (TRIAD – McGill University) | A T N (GM volume) | [18F]AZD4694-PET, SUVR cut-off by visual inspection [18F]MK6240-PET 3 T MRI | MBI-C | MBI-C score | • A linearly correlated with total MBI-C score • No association between T, N and MBI-C score |
6 | Sun et al. 2008 [50] | 995 CU and MCI - 348 depressed (NAME cohort) | A | Sandwich Aβ ELISA | CES-D | Depression | • ↑ A associated with depression (findings likely driven by subjects with MCI) |
7 | Yasuno et al. 2016 [51] | 30 CU | A | PiB-PET, BPND categorized by tertiles | GDS-S | GDS-S score | • ↑ A associated with ↑ GDS-S score |
8 | Krell-Roesch et al. 2016 [52] | 668 CU (MCSA) | N (Glucose metabolism) | FDG-PET, SUVR cut-off < 1.32 in AD-signature ROI | NPI-Q, BAI, BDI-II | Depression, anxiety | • ↓ Glucose metabolism associated with depression, especially in APOE ε4 carriers • ↓ Glucose metabolism associated with ↑ depression and ↑ anxiety symptoms |
9 | Donovan et al. 2015 [53] | 248 CU (HABS) | N (HV, glucose metabolism) A | 3 T MRI, FDG-PET PiB-PET, DVR cut-off > 1.20 | GDS | Depression | • ↓ HV and ↓ glucose metabolism associated with ↑ GDS score • ↓ HV associated with ↑ dysphoria and ↑ apathy-anhedonia scores • ↓ Glucose metabolism associated with ↑ apathy-anhedonia scores • No association between A and GDS score |