Fig. 5

Treatment with δ-secretase inhibitor 11 reduced pathological activation of microglia in SAMP8 mice. a Immunostaining of Iba1, a marker of microglial activation, in the cortex and hippocampus. b, c Density of Iba1-positive cells in the cortex and hippocampus of SAMP8 mice. *P < 0.05, between groups. n = 5 mice per group, unpaired Student’s t-test. d Western blot analysis of Iba1. *P < 0.05, unpaired Student’s t-test; n = 6 mice per group