|
Suárez-Calvet et al. (2020) [84]
|
CN (250)
|
38
|
60.6 ± 4.44
|
8.83 ± 3.21
|
1
|
Simoa - Karikari method
|
|
Moscoso et al. (2021) [85]
|
CN (374)
|
47.1
|
74.8 ± 6.6
|
13.3 ± 10.7
|
1
|
Simoa - Karikari method
|
|
O’Connor et al. (2020) [86]
|
CN (27)
|
41
|
38.1 ± 10.7
|
9.7 ± 9.3
|
1, 2 and 3
|
Simoa - Karikari method
|
|
AD (19)
|
63
|
50.7 ± 10.0
|
23.7 ± 10.5
|
|
Rodriguez et al. (2020) [87]
|
CN (28)
|
35.7
|
82.2 ± 6.5
|
19.3 ± 9.9
|
1, 2 and 3
|
Simoa - Karikari method
|
|
AD (77)
|
46.1
|
81.7 ± 7.6
|
28.4 ± 9.6
|
|
Karikari et al. (2020) - TRIAD cohort [88]
|
CN-young (27)
|
37
|
22.7 ± 1.9
|
7.9 ± 2.6
|
1, 2 and 3
|
Simoa - Karikari method
|
|
CN-old (113)
|
36
|
69.2 ± 9.7
|
10 ± 3.3
|
|
AD (33)
|
55
|
64.6 ± 9.2
|
24.9 ± 7.8
|
|
Karikari et al. (2020) -BioFINDER-2 cohort [88]
|
CN-old (337)
|
46
|
63.1 ± 5.0
|
9.4 ± 6.0
|
1, 2 and 3
|
Simoa - Karikari method
|
|
AD (126)
|
47
|
74.0 ± 6.9
|
19.2 ± 9.4
|
|
Karikari et al. (2020) [45]
|
CN (268)
|
51.1
|
73.5 ± 6.5
|
14.2 ± 9.0
|
1, 2 and 3
|
Simoa - Karikari method
|
|
AD (137)
|
52.2
|
73.4 ± 8.2
|
25.8 ± 8.6
|
|
Mielke et al. (2018) [60]
|
CN (172)
|
69.2
|
71.9 ± 9.5
|
6.4 ± 6.4
|
1, 2 and 3
|
MSD
|
|
AD (40)
|
23
|
67.7 ± 9.2
|
11.6 ± 4.1
|
|
Thijssen et al. (2020) [89]
|
CN (69)
|
53.6
|
60.8 ± 22
|
2.4 ± 3
|
1, 2 and 3
|
MSD
|
|
AD (56)
|
41.1
|
65 ± 9
|
8.4 ± 4
|
|
Janelidze et al. (2020) - Cohort1 [90]
|
CN (26)
|
38.5
|
74 ± 5.2
|
1.3 ± 1.1
|
1, 2 and 3
|
MSD
|
|
AD (38)
|
44.7
|
73 ± 8.1
|
4.4 ± 2.3
|
|
Janelidze et al. (2020) - Cohort2 [90]
|
CN (126)
|
61.9
|
71 ± 5.2
|
1.2 ± 0.59
|
1, 2 and 3
|
MSD
|
|
AD (81)
|
43.2
|
73 ± 5.2
|
2.8 ± 2.07
|
|
Janelidze et al. (2020) – Cohort3 [90]
|
CN (47)
|
59.6
|
83 ± 9.6
|
1.8 ± 1.04
|
1, 2 and 3
|
MSD
|
|
AD (16)
|
75.0
|
83 ± 7.4
|
4 ± 2.07
|
