Study | Subjects (n) | Male (%) | Age, years (mean ± SD) | Plasma tau (pg/ml) | Research question | Method |
---|---|---|---|---|---|---|
Shahim et al. (2014) [27] | CN (47) | NA | 28 ± 14.07 | 4.5 ± 5.66 | 1 | Simoa |
Bogoslovsky et al. (2015) [28] | CN (69) | 51 | 45 ± 15.5 | 4.34 ± 1.77 | 1 | Simoa |
Olivera et al. (2015) [29] | CN (28) | 96.4 | 28.40 ± 4.47 | 0.63 ± 0.48 | 1 | Simoa |
Dage et al. (2016) [30] | CN (378) | 61.4 | 80 ± 5.19 | 4.14 ± 1.56 | 1 | Simoa |
Alosco et al. (2017) [31] | CN (25) | 100 | 55.16 ± 7.95 | 2.46 ± 0.57 | 1 | Simoa |
Mielke et al. (2017) [32] | CN (335) | 62.4 | 80.8 ± 4.8 | 4.2 ± 1.5 | 1 | Simoa |
Müller et al. (2017) [33] | CN (134) | 59.7 | 68.4 ± 5 | 3.6 ± 1.7 | 1 | Simoa |
Kasai et al. (2017) [34] | CN (22) | 54.5 | 37.4 ± 12.0 | 0.470 ± 0.232 | 1 | Simoa |
Foiani et al. (2018) [35] | CN (22) | 41 | 68.7 ± 6.5 | 1.67 ± 0.50 | 1 | Simoa |
Bergman et al. (2018) [36] | CN (36) | 0 | 30 ± 4 | 6.24 ± 2.76 | 1 | Simoa |
Lippa et al. (2018) [37] | CN (42) | 90.5 | 36.21 ± 11.69 | 2.81 ± 1.20 | 1 | Simoa |
Verberk et al. (2018) [38] | CN (191) | 63 | 59 ± 9 | 3.18 ± 1.07 | 1 | Simoa |
Shahim et al. (2018) [39] | CN (19) | NA | 25.0 ± 8.89 | 1.8 ± 1.48 | 1 | Simoa |
Wallace et al. (2018) [40] | CN (13) | 100 | 18.5 ± 1.7 | 2.56 ± 1.02 | 1 | Simoa |
Motamedi et al. (2018) [41] | CN (24) | 91.7 | 30.9 ± 7.77 | 2.48 ± 1.94 | 1 | Simoa |
Fortea et al. (2018) [42] | CN (67) | 30 | 52.05 ± 5.50 | 2.23 ± 1.63 | 1 | Simoa |
Zeitlberger et al. (2018) [43] | CN (13) | 46.2 | 37 | 2.08 ± 1.23 | 1 | Simoa |
Shi et al. (2019) [44] | CN (87) | 41.4 | 64.77 ± 7.40 | 3.56 ± 1.84 | 1 | Simoa |
Kitaguchi et al. (2019) [45] | CN (11) | 45.4 | 67.8 ± 3.71 | 0.63 ± 0.3 | 1 | Simoa |
Pase et al. (2019) [46] | CN (3232) | 46.8 | 58 ± 14 | 3.93 ± 1.11 | 1 | Simoa |
Korley et al. (2019) [47] | CN (63) | 63.5 | 39.0 ± 20.7 | 3.5 ± 3.19 | 1 | Simoa |
Kritikos et al. (2020) [48] | CN (398) | 94.72 | 54.3 ± 8.1 | 1.67 ± 0.685 | 1 | Simoa |
Wolf et al. (2020) [49] | CN (4444) | 42 | 71.9 ± 7.5 | 2.6 ± 2.3 | 1 | Simoa |
Verberk et al. (2020) [50] | CN (241) | 60 | 61.9 ± 10 | 3.1 ± 1 | 1 | Simoa |
Pattinson et al. (2020) [51] | CN (18) | 85.3 | 35.56 ± 12.39 | 2.57 ± 1.01 | 1 | Simoa |
Romero et al. (2020) [52] | CN (3472) | 46 | 54.9 ± 13.2 | 3.9 ± 1.11 | 1 | Simoa |
Petersen et al. (2020) [53] | CN (225) | 51.5 | 45.7 ± 7.1 | 2.4 ± 1.8 | 1 | Simoa |
Cantero et al. (2020) [54] | CN (57) | 47.4 | 67.7 ± 3.4 | 3.1 ± 1.5 | 1 | Simoa |
Zetterberg et al. (2013) [55] | CN (25) | 24 | 74 ± 6.7 | 4.43 ± 2.83 | 1 and 2 | Simoa |
AD (54) | 31.5 | 75 ± 6.2 | 8.80 ± 10.1 | |||
Mattsson et al. (2016) ADNI [56] | CN (189) | 55 | 75.9 ± 4.9 | 2.58 ± 1.19 | 1 and 2 | Simoa |
AD (179) | 52 | 75.2 ± 7.4 | 3.12 ± 1.50 | |||
Mattsson et al. (2016) BioFINDER [56] | CN (274) | 39 | 72.9 ± 4.9 | 5.58 ± 2.51 | 1 and 2 | Simoa |
AD (61) | 42 | 76.4 ± 4.7 | 5.37 ± 2.56 | |||
Shi et al. (2016) [44] | CN (106) | 54.7 | 67.1 ± 7.4 | 2.405 ± 2.76 | 1, 2 and 3 | Simoa |
AD (106) | 53.8 | 69.5 ± 8.1 | 3.870 ± 2.22 | |||
Kovacs et al. (2017) [57] | CN (18) | 50 | 73.7 | 1.68 ± 0.17 | 1 and 2 | Simoa |
AD (21) | 23.8 | 77 | 7.5 ± 3.2 | |||
Deters et al. (2017) [58] | CN (166) | 57.2 | 75.2 ± 5.1 | 2.71 ± 1 | 1 and 2 | Simoa |
AD (168) | 51.8 | 75.3 ± 7.3 | 3.13 ± 1.3 | |||
Chen et al. (2017) [59] | CN (151) | 58.9 | 75.7 ± 4.9 | 2.7 ± 1.1 | 1 and 2 | Simoa |
AD (149) | 55.7 | 76.1 ± 7.3 | 3.2 ± 1.3 | |||
Mielke et al. (2018) [60] | CN (172) | 69.2 | 71.9 ± 9.5 | 5.9 ± 1.90 | 1 and 2 | Simoa |
AD (40) | 23 | 67.7 ± 9.2 | 7.2 ± 2.80 | |||
Park et al. (2019) [61] | CN (172) | 40.4 | 71.08 ± 1.0 | 2.37 ± 0.1 | 1, 2 and 3 | Simoa |
AD (40) | 13.3 | 75.87 ± 2.1 | 3.36 ± 0.3 | |||
Li et al. (2019) [62] | CN (9) | 44.4 | 61.78 ± 10.52 | 4.62 ± 0.50 | 1 and 2 | Simoa |
AD (53) | 42.3 | 68.39 ± 9.65 | 5.47 ± 2.69 | |||
Startin et al. (2019) [63] | CN (27) | 59.3 | 49.26 ± 10.40 | 1.49 ± 1.26 | 1 and 2 | Simoa |
AD (27) | 66.7 | 59.33 ± 4.04 | 1.45 ± 1.02 | |||
Sugarman et al. (2020) [64] | CN (238) | 37.4 | 72.38 ± 7.69 | 3.22 ± 2.73 | 1, 2 and 3 | Simoa |
AD (156) | 55.8 | 76.74 ± 8.12 | 3.73 ± 3.01 | |||
Fossati et al. (2020) [65] | CN (68) | 35.3 | 67.71 ± 8.54 | 2.74 ± 0.76 | 1, 2 and 3 | Simoa |
AD (29) | 34.5 | 72.81 ± 9.69 | 3.67 ± 1.06 | |||
Deniz et al. (2020) [66] | CN (162) | 23.5 | 82.7 ± 8.15 | 3.84 ± 2.27 | 1 and 2 | Simoa |
AD (159) | 31.2 | 78.2 ± 8.97 | 3.75 ± 2.36 | |||
Lin et al. (2018) [67] | CN (35) | 40.0 | 62.6 ± 9.7 | 12.12 ± 0.96 | 1 | IMR |
Chi et al. (2019) [68] | CN (42) | 79 | 59 ± 11.1 | 18.2 ± 13.78 | 1 | IMR |
Chen et al. (2019) [69] | CN (13) | 69.2 | 73 ± 13.0 | 18.7 ± 5.63 | 1 | IMR |
Chen et al. (2020) [70] | CN (28) | 28.6 | 61.1 ± 4.9 | 14.67 ± 8.49 | 1 | IMR |
Fang et al. (2020) [71] | CN -young (43) | 67 | 38.7 ± 13.5 | 14.9 ± 5.5 | 1 | IMR |
CN -old (34) | 41 | 70.3 ± 5.8 | 15.0 ± 7.3 | 1 | ||
Chiu et al. (2017) [72] | CN- middle (56) | 29.1 | 58.1 ± 4.9 | 14.35 ± 6.49 | 1 | IMR |
CN- old (70) | 45.7 | 73.6 ± 6.3 | 18.14 ± 7.33 | 1 | ||
Chiu et al. (2013) [73] | CN (30) | 43.3 | 64.4 ± 9.5 | 15.6 ± 6.9 | 1 and 2 | IMR |
AD (10) | 40 | 69.3 ± 9.4 | 53.9 ± 11.7 | |||
Tzen et al. (2014) [74] | CN (20) | 50 | 63.7 ± 7.9 | 13.5 ± 5.5 | 1 and 2 | IMR |
AD (14) | 28.6 | 64.9 ± 11.5 | 46.7 ± 2.0 | |||
Yang et al. (2017) [75] | CN (66) | NA | 64.6 ± 8.6 | 13.37 ± 7.77 | 1 and 2 | IMR |
AD (29) | 72.2 ± 9.9 | 55.44 ± 22.45 | ||||
Lee et al. (2017) [76] | CN-young (44) | 68.1 | 38.4 ± 13.5 | 14.9 ± 5.5 | 1 and 2 | IMR |
CN-old (34) | 41.2 | 70.3 ± 5.8 | 15.0 ± 7.3 | |||
AD (62) | 46.8 | 72.1 ± 11.1 | 47.5 ± 18.9 | |||
Lue et al. (2017) BSHRI [77] | CN (16) | 25 | 81.9 ± 1.5 | 20.48 ± 1.24 | 1 and 2 | IMR |
AD (16) | 43.8 | 82.5 ± 1.4 | 34.52 ± 3.75 | |||
Lue et al. (2017) NTUH [77] | CN (61) | 39.3 | 64.2 ± 1.1 | 13.98 ± 1.89 | 1 and 2 | IMR |
AD (31) | 54.8 | 72.5 ± 1.8 | 52.47 ± 2.72 | |||
Yang et al. (2018) [78] | CN (23) | NA | 67.5 ± 7.1 | 18.85 ± 10.16 | 1 and 2 | IMR |
AD (21) | 78.8 ± 7.9 | 37.54 ± 12.29 | ||||
Chiu et al. (2019) BSHRI [79] | CN (16) | NA | 81.9 ± 6 | 20.48 ± 4.96 | 1 and 2 | IMR |
AD (16) | 82.5 ± 1.4 | 34.52 ± 14 | ||||
Chiu et al. (2019) NTUH [79] | CN (37) | NA | 66.1 ± 8.3 | 16.61 ± 9.18 | 1 and 2 | IMR |
AD (25) | 78.1 ± 7.3 | 43.35 ± 15.14 | ||||
Jiao et al. (2020) [80] | CN (57) | 45.6 | 67.9 ± 9.5 | 20.65 ± 3.52 | 1 and 2 | IMR |
AD (40) | 37.5 | 68.1 ± 9.0 | 25.91 ± 8.12 | |||
Liu et al. (2020) [81] | CN (2) | 50 | 37 ± 2.8 | 17.4 ± 1.1 | 1 and 2 | IMR |
AD (3) | 33.3 | 71.3 ± 4.0 | 28.3 ± 4.0 | |||
Rubenstein et al. (2017) [82] | CN (20) | 70 | 40.5 ± 14.2 | 0.063 ± 0.014 | 1 | a-EIMAF |
Gardner et al. (2018) [83] | CN-young (79) | 73.4 | 25.8 ± 7.3 | 0.079 ± 0.0087 | 1 | a-EIMAF |
CN-middle-aged (60) | 66.7 | 50.0 ± 5.9 | 0.078 ± 0.008 | |||
CN-older (30) | 63.3 | 68.0 ± 8.4 | 0.079 ± 0.0065 |