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Table 1 Basic characteristics of included studies for plasma tau analysis

From: Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis

Study

Subjects (n)

Male (%)

Age, years (mean ± SD)

Plasma tau (pg/ml)

Research question

Method

Shahim et al. (2014) [27]

CN (47)

NA

28 ± 14.07

4.5 ± 5.66

1

Simoa

Bogoslovsky et al. (2015) [28]

CN (69)

51

45 ± 15.5

4.34 ± 1.77

1

Simoa

Olivera et al. (2015) [29]

CN (28)

96.4

28.40 ± 4.47

0.63 ± 0.48

1

Simoa

Dage et al. (2016) [30]

CN (378)

61.4

80 ± 5.19

4.14 ± 1.56

1

Simoa

Alosco et al. (2017) [31]

CN (25)

100

55.16 ± 7.95

2.46 ± 0.57

1

Simoa

Mielke et al. (2017) [32]

CN (335)

62.4

80.8 ± 4.8

4.2 ± 1.5

1

Simoa

Müller et al. (2017) [33]

CN (134)

59.7

68.4 ± 5

3.6 ± 1.7

1

Simoa

Kasai et al. (2017) [34]

CN (22)

54.5

37.4 ± 12.0

0.470 ± 0.232

1

Simoa

Foiani et al. (2018) [35]

CN (22)

41

68.7 ± 6.5

1.67 ± 0.50

1

Simoa

Bergman et al. (2018) [36]

CN (36)

0

30 ± 4

6.24 ± 2.76

1

Simoa

Lippa et al. (2018) [37]

CN (42)

90.5

36.21 ± 11.69

2.81 ± 1.20

1

Simoa

Verberk et al. (2018) [38]

CN (191)

63

59 ± 9

3.18 ± 1.07

1

Simoa

Shahim et al. (2018) [39]

CN (19)

NA

25.0 ± 8.89

1.8 ± 1.48

1

Simoa

Wallace et al. (2018) [40]

CN (13)

100

18.5 ± 1.7

2.56 ± 1.02

1

Simoa

Motamedi et al. (2018) [41]

CN (24)

91.7

30.9 ± 7.77

2.48 ± 1.94

1

Simoa

Fortea et al. (2018) [42]

CN (67)

30

52.05 ± 5.50

2.23 ± 1.63

1

Simoa

Zeitlberger et al. (2018) [43]

CN (13)

46.2

37

2.08 ± 1.23

1

Simoa

Shi et al. (2019) [44]

CN (87)

41.4

64.77 ± 7.40

3.56 ± 1.84

1

Simoa

Kitaguchi et al. (2019) [45]

CN (11)

45.4

67.8 ± 3.71

0.63 ± 0.3

1

Simoa

Pase et al. (2019) [46]

CN (3232)

46.8

58 ± 14

3.93 ± 1.11

1

Simoa

Korley et al. (2019) [47]

CN (63)

63.5

39.0 ± 20.7

3.5 ± 3.19

1

Simoa

Kritikos et al. (2020) [48]

CN (398)

94.72

54.3 ± 8.1

1.67 ± 0.685

1

Simoa

Wolf et al. (2020) [49]

CN (4444)

42

71.9 ± 7.5

2.6 ± 2.3

1

Simoa

Verberk et al. (2020) [50]

CN (241)

60

61.9 ± 10

3.1 ± 1

1

Simoa

Pattinson et al. (2020) [51]

CN (18)

85.3

35.56 ± 12.39

2.57 ± 1.01

1

Simoa

Romero et al. (2020) [52]

CN (3472)

46

54.9 ± 13.2

3.9 ± 1.11

1

Simoa

Petersen et al. (2020) [53]

CN (225)

51.5

45.7 ± 7.1

2.4 ± 1.8

1

Simoa

Cantero et al. (2020) [54]

CN (57)

47.4

67.7 ± 3.4

3.1 ± 1.5

1

Simoa

Zetterberg et al. (2013) [55]

CN (25)

24

74 ± 6.7

4.43 ± 2.83

1 and 2

Simoa

AD (54)

31.5

75 ± 6.2

8.80 ± 10.1

Mattsson et al. (2016) ADNI [56]

CN (189)

55

75.9 ± 4.9

2.58 ± 1.19

1 and 2

Simoa

AD (179)

52

75.2 ± 7.4

3.12 ± 1.50

Mattsson et al. (2016) BioFINDER [56]

CN (274)

39

72.9 ± 4.9

5.58 ± 2.51

1 and 2

Simoa

AD (61)

42

76.4 ± 4.7

5.37 ± 2.56

Shi et al. (2016) [44]

CN (106)

54.7

67.1 ± 7.4

2.405 ± 2.76

1, 2 and 3

Simoa

AD (106)

53.8

69.5 ± 8.1

3.870 ± 2.22

Kovacs et al. (2017) [57]

CN (18)

50

73.7

1.68 ± 0.17

1 and 2

Simoa

AD (21)

23.8

77

7.5 ± 3.2

Deters et al. (2017) [58]

CN (166)

57.2

75.2 ± 5.1

2.71 ± 1

1 and 2

Simoa

AD (168)

51.8

75.3 ± 7.3

3.13 ± 1.3

Chen et al. (2017) [59]

CN (151)

58.9

75.7 ± 4.9

2.7 ± 1.1

1 and 2

Simoa

AD (149)

55.7

76.1 ± 7.3

3.2 ± 1.3

Mielke et al. (2018) [60]

CN (172)

69.2

71.9 ± 9.5

5.9 ± 1.90

1 and 2

Simoa

AD (40)

23

67.7 ± 9.2

7.2 ± 2.80

Park et al. (2019) [61]

CN (172)

40.4

71.08 ± 1.0

2.37 ± 0.1

1, 2 and 3

Simoa

AD (40)

13.3

75.87 ± 2.1

3.36 ± 0.3

Li et al. (2019) [62]

CN (9)

44.4

61.78 ± 10.52

4.62 ± 0.50

1 and 2

Simoa

AD (53)

42.3

68.39 ± 9.65

5.47 ± 2.69

Startin et al. (2019) [63]

CN (27)

59.3

49.26 ± 10.40

1.49 ± 1.26

1 and 2

Simoa

AD (27)

66.7

59.33 ± 4.04

1.45 ± 1.02

Sugarman et al. (2020) [64]

CN (238)

37.4

72.38 ± 7.69

3.22 ± 2.73

1, 2 and 3

Simoa

AD (156)

55.8

76.74 ± 8.12

3.73 ± 3.01

Fossati et al. (2020) [65]

CN (68)

35.3

67.71 ± 8.54

2.74 ± 0.76

1, 2 and 3

Simoa

AD (29)

34.5

72.81 ± 9.69

3.67 ± 1.06

Deniz et al. (2020) [66]

CN (162)

23.5

82.7 ± 8.15

3.84 ± 2.27

1 and 2

Simoa

AD (159)

31.2

78.2 ± 8.97

3.75 ± 2.36

Lin et al. (2018) [67]

CN (35)

40.0

62.6 ± 9.7

12.12 ± 0.96

1

IMR

Chi et al. (2019) [68]

CN (42)

79

59 ± 11.1

18.2 ± 13.78

1

IMR

Chen et al. (2019) [69]

CN (13)

69.2

73 ± 13.0

18.7 ± 5.63

1

IMR

Chen et al. (2020) [70]

CN (28)

28.6

61.1 ± 4.9

14.67 ± 8.49

1

IMR

Fang et al. (2020) [71]

CN -young (43)

67

38.7 ± 13.5

14.9 ± 5.5

1

IMR

CN -old (34)

41

70.3 ± 5.8

15.0 ± 7.3

1

Chiu et al. (2017) [72]

CN- middle (56)

29.1

58.1 ± 4.9

14.35 ± 6.49

1

IMR

CN- old (70)

45.7

73.6 ± 6.3

18.14 ± 7.33

1

Chiu et al. (2013) [73]

CN (30)

43.3

64.4 ± 9.5

15.6 ± 6.9

1 and 2

IMR

AD (10)

40

69.3 ± 9.4

53.9 ± 11.7

Tzen et al. (2014) [74]

CN (20)

50

63.7 ± 7.9

13.5 ± 5.5

1 and 2

IMR

AD (14)

28.6

64.9 ± 11.5

46.7 ± 2.0

Yang et al. (2017) [75]

CN (66)

NA

64.6 ± 8.6

13.37 ± 7.77

1 and 2

IMR

AD (29)

72.2 ± 9.9

55.44 ± 22.45

Lee et al. (2017) [76]

CN-young (44)

68.1

38.4 ± 13.5

14.9 ± 5.5

1 and 2

IMR

CN-old (34)

41.2

70.3 ± 5.8

15.0 ± 7.3

AD (62)

46.8

72.1 ± 11.1

47.5 ± 18.9

Lue et al. (2017) BSHRI [77]

CN (16)

25

81.9 ± 1.5

20.48 ± 1.24

1 and 2

IMR

AD (16)

43.8

82.5 ± 1.4

34.52 ± 3.75

Lue et al. (2017) NTUH [77]

CN (61)

39.3

64.2 ± 1.1

13.98 ± 1.89

1 and 2

IMR

AD (31)

54.8

72.5 ± 1.8

52.47 ± 2.72

Yang et al. (2018) [78]

CN (23)

NA

67.5 ± 7.1

18.85 ± 10.16

1 and 2

IMR

AD (21)

78.8 ± 7.9

37.54 ± 12.29

Chiu et al. (2019) BSHRI [79]

CN (16)

NA

81.9 ± 6

20.48 ± 4.96

1 and 2

IMR

AD (16)

82.5 ± 1.4

34.52 ± 14

Chiu et al. (2019) NTUH [79]

CN (37)

NA

66.1 ± 8.3

16.61 ± 9.18

1 and 2

IMR

AD (25)

78.1 ± 7.3

43.35 ± 15.14

Jiao et al. (2020) [80]

CN (57)

45.6

67.9 ± 9.5

20.65 ± 3.52

1 and 2

IMR

AD (40)

37.5

68.1 ± 9.0

25.91 ± 8.12

Liu et al. (2020) [81]

CN (2)

50

37 ± 2.8

17.4 ± 1.1

1 and 2

IMR

AD (3)

33.3

71.3 ± 4.0

28.3 ± 4.0

Rubenstein et al. (2017) [82]

CN (20)

70

40.5 ± 14.2

0.063 ± 0.014

1

a-EIMAF

Gardner et al. (2018) [83]

CN-young (79)

73.4

25.8 ± 7.3

0.079 ± 0.0087

1

a-EIMAF

CN-middle-aged (60)

66.7

50.0 ± 5.9

0.078 ± 0.008

CN-older (30)

63.3

68.0 ± 8.4

0.079 ± 0.0065