Fig. 4

Diagnostic accuracy of plasma tau and ptau181. a–c Forest plots of pooled sensitivity and specificity (a), HSROC curve (b), and Fagan’s nomogram (c) to estimate the clinical utility of plasma tau detected by the Simoa method. d–f The forest plots of pooled sensitivity and specificity (d), HSROC curve (e) and Fagan’s nomogram (f) to estimate the clinical utility of plasma ptau181 detected by the Simoa method