Fig. 4From: An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseasesDiagram of piRNA functions in neurodegenerative diseases. piRNAs could cause transposon dysregulation, increase heterochromatin formation and DNA methylation, silence the ubiquitin-proteasome and autophagy-lysosome systems, and thus result in increased levels of misfolded proteinBack to article page