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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Ecto-GPR37: a potential biomarker for Parkinson’s disease

Fig. 2

Ecto-GPR37 peptides detected in human CSF. a Mass spectrometric results (see Supplementary Methods) of human ecto-GPR37 peptides immunoprecipitated from the pooled CSF of NC (n = 10) or PD subjects (n = 10). The detected peptide sequences in the CSF of NC and PD are indicated (M + H+) and their estimated abundance was expressed as the area from the extracted ion chromatograms (XIC) of the peptide chromatographic peak. NA, not quantified. b Schematic representation showing the precise location of the mass spectrometry-detected ecto-GPR37 peptides (black circles) within the N-terminal domain (N-term) of the receptor. The theoretical molecular weight (kDa) based on the amino acid sequence of human GPR37 is indicated (arrows). The seven transmembrane (TM) domains of the receptor embedded within the membrane are highlighted in grey. The three extracellular loops (ECL) are also indicated. The GPR37 scheme was made using the GPCRdb resource [36]

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