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Table 2 Studies on OCTA parameters in patients with AD, MCI and preclinical AD

From: Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease

Authors Year of publication Parameters Subjects Alteration
Bulut M et al. [71] 2018 SRCP-VD, DRCP-VD, FAZ AD Lower VD, enlarged FAZ.
Lahme L et al. [72] 2018 SRCP-flow density, DRCP-flow density, Peripapillary-VD AD Lower SRCP-flow density
Jiang et al. [73] 2017 SRCP-VD, DRCP-VD AD
MCI
AD had lower VD of SRCP and DRCP. MCI had lower VD of DRCP in the superior nasal quadrant
Stephen P et al. [74] 2019 SRCP-VD, FAZ AD
MCI
AD had lower SRCP-VD. No difference in MCI
Zhang et al. [75] 2019 SRCP-VD, DRCP-VD, RPC MCI or early AD Lower SRCP-VD
Wu et al. [76] 2020 SRCP-VD, DRCP-VD, FAZ AD
MCI
Lower DRCP-VD
O’Bryhim et al. [77] 2018 SRCP-VD, FAZ Preclinical AD Lower VD, enlarged FAZ
van de Kreeke et al. [78] 2020 Macular-VD, Peripapillary-VD, FAZ Preclinical AD Higher VD, no difference in FAZ.
  1. OCT optical coherence tomography; AD Alzheimer’s disease; MCI mild cognitive impairment; SRCP-VD superficial retinal capillary plexus-vessel density; DRCP-VD deep retinal capillary plexus-vessel density; RPC radial peripapillary capillary; FAZ foveal avascular zone