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Table 2 Studies on OCTA parameters in patients with AD, MCI and preclinical AD

From: Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease

Authors

Year of publication

Parameters

Subjects

Alteration

Bulut M et al. [71]

2018

SRCP-VD, DRCP-VD, FAZ

AD

Lower VD, enlarged FAZ.

Lahme L et al. [72]

2018

SRCP-flow density, DRCP-flow density, Peripapillary-VD

AD

Lower SRCP-flow density

Jiang et al. [73]

2017

SRCP-VD, DRCP-VD

AD

MCI

AD had lower VD of SRCP and DRCP. MCI had lower VD of DRCP in the superior nasal quadrant

Stephen P et al. [74]

2019

SRCP-VD, FAZ

AD

MCI

AD had lower SRCP-VD. No difference in MCI

Zhang et al. [75]

2019

SRCP-VD, DRCP-VD, RPC

MCI or early AD

Lower SRCP-VD

Wu et al. [76]

2020

SRCP-VD, DRCP-VD, FAZ

AD

MCI

Lower DRCP-VD

O’Bryhim et al. [77]

2018

SRCP-VD, FAZ

Preclinical AD

Lower VD, enlarged FAZ

van de Kreeke et al. [78]

2020

Macular-VD, Peripapillary-VD, FAZ

Preclinical AD

Higher VD, no difference in FAZ.

  1. OCT optical coherence tomography; AD Alzheimer’s disease; MCI mild cognitive impairment; SRCP-VD superficial retinal capillary plexus-vessel density; DRCP-VD deep retinal capillary plexus-vessel density; RPC radial peripapillary capillary; FAZ foveal avascular zone