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Table 1 Studies on OCT parameters in patients with AD, MCI and preclinical AD

From: Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease

Authors Year of publication Layer Subjects Alteration
Parisi et al. [40] 2001 pRNFL AD Thinning
Iseri et al. [41] 2006 pRNFL, mRNFL AD Thinning
Berisha et al. [42] 2007 pRNFL AD Thinner in the superior quadrant
Lu et al. [43] 2010 pRNFL AD Thinner in the superior and inferior quadrants
Moschos et al. [44] 2012 pRNFL AD Thinning
Kirbas et al. [45] 2013 pRNFL AD Thinner in the superior quadrant
Marziani E et al. [46] 2013 mRNFL
mRNFL + GCL
AD Thinning
Garcia-Martin et al. [47] 2016 pRNFL, mRNFL GCL, IPL, INL, OPL, ONL, RPE AD Thinner pRNFL, mRNFL, GCL, and IPL
Gharbiya et al. [48] 2014 pRNFL AD No difference
Larrosa et al. [49] 2014 pRNFL AD Thinning except the nasal quadrant.
Kromer et al. [50] 2014 pRNFL AD Thinner in the nasal superior sector
Polo V et al. [51] 2017 pRNFL AD Thinner in the superior and inferior quadrants.
Salobrar-Garcia et al. [52] 2015 pRNFL, mRNFL AD Thinner mRNFL
Eraslan et al. [53] 2015 pRNFL, GCC AD Thinning
La Morgia et al. [54] 2016 pRNFL AD Thinning
Cunha et al. [55] 2017 pRNFL AD Thinner in the temporal superior quadrants and globally
Liu et al. [56] 2015 pRNFL AD Mild and moderate AD had thinner pRNFL in the superior quadrant. Severe AD had thinner pRNFL in the superior and inferior quadrants.
Ferrari L et al. [57] 2017 pRNFL, pGC-IPL AD
MCI
No difference in mild AD. Moderate AD had thinner pRNFL and pGC-IPL. MCI had thinner pRNFL.
Paquet et al. [58] 2007 pRNFL AD
MCI
Thinning
Kesler et al. [59] 2011 pRNFL AD
MCI
AD had thinner pRNFL in the superior and inferior quadrants. MCI had thinner pRNFL only in the inferior quadrant.
Ascaso et al. [60] 2014 pRNFL AD
MCI
AD had thinner pRNFL in all sectors. MCI had thinner pRNFL in all sectors except the temporal quadrant.
Gao et al. [61] 2015 pRNFL AD
MCI
Thinning
Oktem et al. [62] 2015 pRNFL AD
MCI
Thinning
Cheung et al. [63] 2015 pRNFL, GC-IPL AD
MCI
AD had thinner pRNFL in the superior quadrant and thinner mGC-IPL in all sectors.
MCI had thinner mGC-IPL in the majority of sectors.
Shao et al. [64] 2018 pRNFL, GC-IPL AD
MCI
Thinning
Almeida et al. [65] 2019 pRNFL, mRNFL MCI Thinner mRNFL, mGC-IPL and mGCC
Santos et al. [66] 2018 pRNFL, mRNFL, GCL, IPL, OPL, INL, ONL Preclinical AD Thinner mRNFL, ONL and IPL
López-Cuenca et al. [67] 2020 pRNFL, mRNFL, GCL, IPL, INL, OPL, ONL, RPE Preclinical AD Thinner mRNFL, IPL, INL and OPL
Snyder et al. [68] 2016 pRNFL, mRNFL, GCL, IPL, INL, OPL, ONL, Preclinical AD Thicker IPL
van de Kreeke et al. [69] 2019 pRNFL, mRNFL, GCL, IPL, Preclinical AD No difference
van de Kreeke et al. [70] 2020 pRNFL, mRNFL, GCL, IPL, Preclinical AD No difference in the rate of change of any retinal layers
  1. OCT optical coherence tomography; AD Alzheimer’s disease; MCI mild cognitive impairment; pRNFL peripapillary retinal nerve fiber layer; mRNFL macular retinal nerve fiber layer; GCL ganglion cell layer; IPL inner plexiform layer; GC-IPL ganglion cell-inner plexiform layer; pGC-IPL peripapillary ganglion cell-inner plexiform layer; mGCC macular ganglion cell complex; INL inner nuclear layer; OPL outer plexiform layer; ONL outer nuclear layer; RPE retinal pigment epithelium