Table 1 Studies on OCT parameters in patients with AD, MCI and preclinical AD
From: Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease
| Authors | Year of publication | Layer | Subjects | Alteration |
|---|---|---|---|---|
| Parisi et al. [40] | 2001 | pRNFL | AD | Thinning |
| Iseri et al. [41] | 2006 | pRNFL, mRNFL | AD | Thinning |
| Berisha et al. [42] | 2007 | pRNFL | AD | Thinner in the superior quadrant |
| Lu et al. [43] | 2010 | pRNFL | AD | Thinner in the superior and inferior quadrants |
| Moschos et al. [44] | 2012 | pRNFL | AD | Thinning |
| Kirbas et al. [45] | 2013 | pRNFL | AD | Thinner in the superior quadrant |
| Marziani E et al. [46] | 2013 |
mRNFL mRNFL + GCL | AD | Thinning |
| Garcia-Martin et al. [47] | 2016 | pRNFL, mRNFL GCL, IPL, INL, OPL, ONL, RPE | AD | Thinner pRNFL, mRNFL, GCL, and IPL |
| Gharbiya et al. [48] | 2014 | pRNFL | AD | No difference |
| Larrosa et al. [49] | 2014 | pRNFL | AD | Thinning except the nasal quadrant. |
| Kromer et al. [50] | 2014 | pRNFL | AD | Thinner in the nasal superior sector |
| Polo V et al. [51] | 2017 | pRNFL | AD | Thinner in the superior and inferior quadrants. |
| Salobrar-Garcia et al. [52] | 2015 | pRNFL, mRNFL | AD | Thinner mRNFL |
| Eraslan et al. [53] | 2015 | pRNFL, GCC | AD | Thinning |
| La Morgia et al. [54] | 2016 | pRNFL | AD | Thinning |
| Cunha et al. [55] | 2017 | pRNFL | AD | Thinner in the temporal superior quadrants and globally |
| Liu et al. [56] | 2015 | pRNFL | AD | Mild and moderate AD had thinner pRNFL in the superior quadrant. Severe AD had thinner pRNFL in the superior and inferior quadrants. |
| Ferrari L et al. [57] | 2017 | pRNFL, pGC-IPL |
AD MCI | No difference in mild AD. Moderate AD had thinner pRNFL and pGC-IPL. MCI had thinner pRNFL. |
| Paquet et al. [58] | 2007 | pRNFL |
AD MCI | Thinning |
| Kesler et al. [59] | 2011 | pRNFL |
AD MCI | AD had thinner pRNFL in the superior and inferior quadrants. MCI had thinner pRNFL only in the inferior quadrant. |
| Ascaso et al. [60] | 2014 | pRNFL |
AD MCI | AD had thinner pRNFL in all sectors. MCI had thinner pRNFL in all sectors except the temporal quadrant. |
| Gao et al. [61] | 2015 | pRNFL |
AD MCI | Thinning |
| Oktem et al. [62] | 2015 | pRNFL |
AD MCI | Thinning |
| Cheung et al. [63] | 2015 | pRNFL, GC-IPL |
AD MCI |
AD had thinner pRNFL in the superior quadrant and thinner mGC-IPL in all sectors. MCI had thinner mGC-IPL in the majority of sectors. |
| Shao et al. [64] | 2018 | pRNFL, GC-IPL |
AD MCI | Thinning |
| Almeida et al. [65] | 2019 | pRNFL, mRNFL | MCI | Thinner mRNFL, mGC-IPL and mGCC |
| Santos et al. [66] | 2018 | pRNFL, mRNFL, GCL, IPL, OPL, INL, ONL | Preclinical AD | Thinner mRNFL, ONL and IPL |
| López-Cuenca et al. [67] | 2020 | pRNFL, mRNFL, GCL, IPL, INL, OPL, ONL, RPE | Preclinical AD | Thinner mRNFL, IPL, INL and OPL |
| Snyder et al. [68] | 2016 | pRNFL, mRNFL, GCL, IPL, INL, OPL, ONL, | Preclinical AD | Thicker IPL |
| van de Kreeke et al. [69] | 2019 | pRNFL, mRNFL, GCL, IPL, | Preclinical AD | No difference |
| van de Kreeke et al. [70] | 2020 | pRNFL, mRNFL, GCL, IPL, | Preclinical AD | No difference in the rate of change of any retinal layers |