Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions

Table 2 Comparison of human α-syn overexpression mouse models

Promotor	CNP	MBP^*	PLP
Phosphorylated α-syn aggregates in OLGs	++	++	++
Neuronal loss
Striatonigral system	–	++^**	++
Olivopontocerebellar system	ND	ND	–
Spinal cord	+	–	++^***
Demyelination	+	++	–
Microglial activation	ND	++	++
Phenotype
Motor	++	++	+
Non-motor	–	ND	++
Reference	[173, 174]	[175, 176]	[177, 178]

The results of immunohistochemical and phenotypic analysis of each MSA mouse model are highlighted.
++, present within 12 months of age; +, present after 12 months of age; −, not clearly observed; ND, not described. ^*, moderate expresser line; ^**, not significant in substantia nigra; ^***, mainly parasympathetic outflow

ISSN: 2047-9158