Fig. 3
From: Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
Hypothetical schema showing OLG-to-OLG propagation and accumulation of pathological α-syn. Pathological α-syn with seeding property hypothetically propagates from OLG to OLG leading to the spreading of GCI pathology. Given that the uptake of extracellularly-applied misfolded α-syn is not usually observed in normal OLGs, the entry of misfolded α-syn into oligodendroglial cells is mediated through an unidentified mechanism (a-c). Once the misfolded α-syn (pre-GCI) enters oligodendroglial cells, the pre-GCI self-assembles through the interaction with non-misfolded α-syn, resulting in the formation of perinuclear fibrillary structure (mature GCIs). The non-misfolded α-syn may be derived from OLGs or neurons (d, e)