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Table 2 Conflicting results regarding mitochondria reported in primary fibroblasts from PD patients with parkin mutations

From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

Parameter

Reported observations

Δψ

Lower Δψ [143, 146]

No differences in Δψ [142, 148]

Complex I activity

Decreased complex I activity [143, 147]

No changes in complex I activity [144]

ATP production

Reduced cellular ATP levels [143, 145, 146]

Higher cellular ATP levels with increased glycolysis [147]

Mitochondrial morphology

Higher form factor [143]

Lower form factor [148]

No changes in form factor [68, 142, 144, 145]

Unaffected mitochondrial aspect ratio [142, 145, 148]

Mitochondrial mass

Increased mitochondrial mass [144]

Unaffected mitochondrial mass [142, 145]

Mitochondrial respiration

Increased basal oxygen consumption [146, 148]

Lower basal oxygen consumption [147]

Reduced uncoupled respiration rates [147]

Decreased basal/maximal respiratory ratio in galactose media [142]