From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
Parameter | Reported observations |
---|---|
Δψ | |
Complex I activity | Decreased complex I activity [143, 147] No changes in complex I activity [144] |
ATP production | Reduced cellular ATP levels [143, 145, 146] Higher cellular ATP levels with increased glycolysis [147] |
Mitochondrial morphology | Higher form factor [143] Lower form factor [148] |
Mitochondrial mass | Increased mitochondrial mass [144] |
Mitochondrial respiration | Increased basal oxygen consumption [146, 148] Lower basal oxygen consumption [147] Reduced uncoupled respiration rates [147] Decreased basal/maximal respiratory ratio in galactose media [142] |