Skip to main content

Table 2 Conflicting results regarding mitochondria reported in primary fibroblasts from PD patients with parkin mutations

From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

Parameter Reported observations
Δψ Lower Δψ [143, 146]
No differences in Δψ [142, 148]
Complex I activity Decreased complex I activity [143, 147]
No changes in complex I activity [144]
ATP production Reduced cellular ATP levels [143, 145, 146]
Higher cellular ATP levels with increased glycolysis [147]
Mitochondrial morphology Higher form factor [143]
Lower form factor [148]
No changes in form factor [68, 142, 144, 145]
Unaffected mitochondrial aspect ratio [142, 145, 148]
Mitochondrial mass Increased mitochondrial mass [144]
Unaffected mitochondrial mass [142, 145]
Mitochondrial respiration Increased basal oxygen consumption [146, 148]
Lower basal oxygen consumption [147]
Reduced uncoupled respiration rates [147]
Decreased basal/maximal respiratory ratio in galactose media [142]