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Fig. 6 | Translational Neurodegeneration

Fig. 6

From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

Fig. 6

Model of disintegration of the ER–mitochondrial contact sites upon mitochondrial depolarization. Under basal conditions, the contacts between the ER and mitochondria are mediated by various proteins, including Mfn2, ubiquitination of which at K416 was suggested to promote the interaction (left panel). Upon mitochondrial depolarization, Mfn2 is polyubiquitinated and is removed from the membrane for proteasomal degradation, resulting in disruption of the ER–mitochondria contact sites and drifting of these organelles away from each other (right panel)

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