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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

Fig. 5

Model of the PINK1/Parkin-mediated arrest of mitochondrial motility upon mitochondrial depolarization. Mitochondria are attached to the motor protein kinesin on the microtubules via adaptors TRAK and Miro with Miro anchored in MOM (left panel). Parkin possibly interacts with Miro before mitochondria are damaged (middle panel). After stabilization of PINK1 on MOM, activated Parkin catalyses monoubiquitination of Miro at multiple sites (right panel), resulting in dissociation of the mitochondria from the microtubules

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