|
Biochemical indicator
|
vs HC
|
vs ONDsa
|
|---|
|
No. of studies
|
No. of ALS/controls
|
WMD
|
Lower 95%CI
|
High 95% CI
|
p value
|
No. of studies
|
No. of ALS/controls
|
WMD
|
Lower 95%CI
|
High 95% CI
|
p value
|
|---|
|
Total cholesterol
|
16
|
2762/4479
|
3.98
|
−3.48
|
11.44
|
0.30
|
1
|
39/66
|
10.87
|
−1.22
|
22.96
|
0.08
|
|
LDL-C
|
13
|
2677/4347
|
0.46
|
−6.56
|
7.47
|
0.90
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
HDL-C
|
14
|
2707/4376
|
1.67
|
−0.89
|
4.24
|
0.20
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
TG
|
11
|
2366/2261
|
0.11
|
−9.15
|
9.37
|
0.98
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
Fasting blood glucose
|
8
|
220/204
|
0.13
|
0.05
|
0.21
|
0.001
|
1
|
81/37
|
0.20
|
−0.23
|
0.63
|
0.37
|
|
Fasting insulin
|
6
|
94/88
|
−6.79
|
−29.27
|
15.70
|
0.55
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
CSF glucose
|
1
|
20/20
|
−0.05
|
−0.37
|
0.27
|
0.76
|
2
|
112/71
|
0.06
|
−0.10
|
0.21
|
0.45
|
|
CSF total proteinb
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
5
|
312/153
|
−1.45
|
−5.13
|
2.24
|
0.44
|
|
Qalb
|
1
|
14/20
|
2.00
|
−2.94
|
6.94
|
0.43
|
5
|
508/180
|
0.46
|
−0.55
|
1.47
|
0.37
|
|
Serum albumin
|
3
|
630/611
|
−1.52
|
−5.53
|
2.48
|
0.46
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
Serum total protein
|
3
|
705/690
|
−0.44
|
−1.03
|
0.14
|
0.14
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
Serum ferritin
|
9
|
1638/1217
|
63.43
|
48.12
|
78.73
|
< 0.001
|
2
|
572/255
|
58.72
|
29.23
|
88.21
|
< 0.001
|
|
Serum transferrinc
|
6
|
974/659
|
−0.13
|
−0.17
|
−0.08
|
< 0.001a
|
2
|
184/83
|
0.81
|
−1.34
|
2.96
|
0.46
|
|
Serum iron
|
6
|
974/659
|
0.34
|
−0.68
|
1.37
|
0.51
|
1
|
72/38
|
−0.49
|
−2.70
|
1.71
|
0.66
|
|
TIBC
|
3
|
236/304
|
−2.42
|
−3.93
|
−0.90
|
0.002
|
1
|
72/38
|
−1.74
|
−5.39
|
1.91
|
0.35
|
|
TSC %
|
3
|
858/486
|
2.79
|
1.52
|
4.05
|
< 0.001
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
Creatine kinase
|
5
|
229/1843
|
80.29
|
32.90
|
127.67
|
0.001
|
0
|
NA
|
NA
|
NA
|
NA
|
NA
|
- Abbreviations: ALS amyotrophic lateral sclerosis, CI confidence interval, CSF cerebrospinal fluid, HC healthy control, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, NA not available, OND other neurological disease, Qalb CSF/serum albumin quotient, TG triglyceride, TIBC total iron-binding capacity, TSC% transferrin saturation coefficient, WMD weighted mean difference
- a: ONDs are other neurological diseases excluding ALS-related disease. Note: only one study compared ALS with lower motor neuron disease on total protein in CSF [Süssmuth. S. 2010]
- b: Süssmuth. S et al. compared total protein in CSF and Qalb between ALS patients and lower motor neuron disease but the results did not have statistical significance (CSF total protein: WMD = −6.90, 95% CI [− 36.23–22.43], p = 0.65; Qalb: WMD = 2.00, 95% CI [−2.94–6.94], p = 0.47)
- c: By performing a separate analysis based on control group, serum transferrin showed a significant decrease in ALS patients compared with healthy controls other than ONDs
