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Table 1 Summary of comparative outcomes for measurements of biochemical indicators in blood and CSF

From: Aberrations of biochemical indicators in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Biochemical indicator No. of studies No. of ALS/controls* Main effect Heterogeneity   Publication bias
WMD Lower 95%CI High 95% CI z score p value df p value I2 statistic Egger intercept p value
Total cholesterol 17 2801/4545 4.44 −2.62 11.50 1.23 0.22 21 < 0.001 89.40% 1.42 0.23
LDL-C 13 2677/4347 0.46 −6.56 7.47 0.13 0.90 16 < 0.001 95.10% 0.24 0.88
HDL-C 14 2707/4376 1.67 −0.89 4.24 1.28 0.20 17 < 0.001 86.70% 2.57 0.02
TG 11 2366/2261 0.11 −9.15 9.37 0.02 0.98 12 < 0.001 83.90% −2.13 0.05
Fasting blood glucose 9 301/241 0.13 0.06 0.21 3.38 0.001 9 0.39 5.60% 0.51 0.35
Fasting insulin 6 94/88 −6.79 −29.27 15.70 0.59 0.55 6 < 0.001 89.70% 2.19 0.59
CSF glucose 3 132/91 0.04 −0.10 0.18 0.54 0.59 2 0.18 41.50% 1.91 0.56
CSF total protein 6 417/165 −1.53 −5.19 2.12 1.31 0.19 4 0.64 0.00% −0.11 0.89
Qalb 7 627/212 0.44 −0.51 1.39 0.91 0.36 6 0.001 72.20% −0.47 0.72
Serum albumin 3 630/611 −1.52 −5.53 2.48 0.74 0.46 2 < 0.001 94.80% 5.37 0.002
Serum total protein 3 705/690 −0.44 −1.03 0.14 1.49 0.14 2 < 0.001 98.80% 15.64 0.25
Serum ferritin 9 1661/1219 63.42 48.12 78.73 8.12 < 0.001 15 0.001 67.60% 1.89 0.06
Serum transferrin 7 1163/718 0.07 −0.58 0.72 0.21 0.83 10 < 0.001 99.60% −0.41 0.96
Serum iron 6 974/659 0.34 −0.68 1.36 0.66 0.51 7 0.012 61.10% −2.18 0.15
TIBC 3 236/304 −2.42 −3.93 −0.90 3.12 0.002 3 0.29 19.60% 0.05 0.99
TSC % 3 858/486 2.79 1.52 4.05 4.33 < 0.001 3 0.96 0 1.02 0.35
Creatine kinase 5 229/1843 80.29 32.90 127.67 3.32 0.001 6 < 0.001 93.20% 5.51 0.27
  1. Abbreviations: ALS amyotrophic lateral sclerosis, CSF cerebrospinal fluid, df degrees of freedom, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, NA not available, Qalb CSF/serum albumin quotient, TC total cholesterol, TG triglyceride, TIBC total iron binding capacity, TSC transferrin saturation coefficient, WMD weighted mean difference. * controls include healthy controls and other neurological diseases controls