Model | Model characteristics | Reference |
---|---|---|
Fibroblasts of patients | Carriers of heterozygous GBA mutations without or with PD | [102] |
Fibroblasts of PD patients | Heterozygous GBA L444P and N370S mutations | [103] |
Dopaminergic neurons derived from iPSC (patient midbrain) | Carriers of heterozygous GBA variant N370S in twins discordant for PD. | [104] |
Mouse model | Heterozygous GBA variant L444P | [105] |
SH-SY5Y cells (human α-synuclein) | siRNA knockdown of GBA | [106] |
Mouse | GBA knockout | [107] |
Mouse | GBA point mutations (D409H, N370S, D409V, and V394L) | [108] |
Zebrafish | Deletion of 23 bp GBA | [109] |
Mouse | GBA L444P mutation + α-synuclein A53T mutation | [90] |
NSC and dopaminergic cells derived from the iPSC and fibroblasts of patients | Heterozygous GBA N370S mutations | [110] |
Embryonic fibroblasts from mice | GBA heterozygous mutation | [111] |