Fig. 2From: Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive reviewMechanisms underlying the GCase–α-synuclein cross-talk that results in pathological conditions. GCase alterations induce disruptions of lipid composition and protein trafficking, inducing aggregation of α-synucleinBack to article page