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Table 5 Neuropsychiatric symptoms (Factors) among cognitively intact DIAD mutation carriers

From: Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

  Regression estimate 95% CI p value
Age − 0.076 − 0.016, − 0.002 <  0.001
EYO − 0.070 − 0.101, − 0.038 <  0.001
Factor 1 Agitation + Disinhibition + Irritability + Depression
0.010 − 0.024, 0.022 0.367
Factor 2 Anxiety + Apathy + Depression + Motor + Sleep changes
− 0.026 − 0.049, − 0.004 0.023
Factor 3 Delusion + Sleep changes + Irritability
0.008 − 0.014, 0.031 0.478
Factor 4 Appetite + Anxiety
− 0.004 − 0.020, 0.012 0.481
2-Way Interactions
Factor 1 X EYO − 0.044 − 0.071, 0.017 0.001
Factor 2 X EYO − 0.020 − 0.047, 0.007 0.140
Factor 3 X EYO 0.006 − 0.020, 0.033 0.637
Factor 4 X EYO − 0.005 − 0.026, 0.016 0.649
  1. Mixed Model with family-level random-effects, corrected for 2-way interactions of Factors (1 to 4) X age, 3-way interactions Factors (1 to 4) X Age X EYO, gender, APOE, education and family mutation type