Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

Table 5 Neuropsychiatric symptoms (Factors) among cognitively intact DIAD mutation carriers

	Regression estimate	95% CI	p value
Age	− 0.076	− 0.016, − 0.002	< 0.001
EYO	− 0.070	− 0.101, − 0.038	< 0.001
Factor 1	Agitation + Disinhibition + Irritability + Depression
Factor 1	0.010	− 0.024, 0.022	0.367
Factor 2	Anxiety + Apathy + Depression + Motor + Sleep changes
Factor 2	− 0.026	− 0.049, − 0.004	0.023
Factor 3	Delusion + Sleep changes + Irritability
Factor 3	0.008	− 0.014, 0.031	0.478
Factor 4	Appetite + Anxiety
Factor 4	− 0.004	− 0.020, 0.012	0.481
2-Way Interactions
Factor 1 X EYO	− 0.044	− 0.071, 0.017	0.001
Factor 2 X EYO	− 0.020	− 0.047, 0.007	0.140
Factor 3 X EYO	0.006	− 0.020, 0.033	0.637
Factor 4 X EYO	− 0.005	− 0.026, 0.016	0.649

Mixed Model with family-level random-effects, corrected for 2-way interactions of Factors (1 to 4) X age, 3-way interactions Factors (1 to 4) X Age X EYO, gender, APOE, education and family mutation type

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