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Table 2 Neuropsychiatric symptoms among cognitively intact DIAD mutation carriers and non-carriers

From: Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

 

DIAD mutation non-carriers (n = 102)

DIAD mutation carriers (n = 119)

p value

NPI-Q Score

0.64 (1.23)

0.88 (2.19)

0.338

NPI-Q Sub-scale

 Agitation

0.07 (0.29)

0.08 (0.40)

0.699

 Anxiety

0.10 (0.35)

0.11 (0.33)

0.856

 Apathy

0.01 (0.09)

0.04 (0.27)

0.295

 Appetite

0.10 (0.41)

0.10 (0.39)

0.525

 Delusion

0.00 (0.00)

0.01 (0.09)

–

 Depression

0.13 (0.43)

0.13 (0.46)

0.748

 Disinhibition

0.01 (0.09)

0.03 (0.27)

0.609

 Elation

0.02 (0.13)

0.00 (0.00)

0.055

 Hallucination

0.00 (0.00)

0.00 (0.00)

–

 Irritability

0.12 (0.40)

0.18 (0.56)

0.207

 Motor

0.02 (0.19)

0.05 (0.28)

0.366

 Sleep changes

0.07 (0.35)

0.14 (0.47)

0.195

  1. Mixed Model with family-level random-effects, corrected for age, gender, APOE, education and family mutation type
  2. NPI-Q neuropsychiatric inventory-questionnaire
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Translational Neurodegeneration

ISSN: 2047-9158

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