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Table 2 Neuropsychiatric symptoms among cognitively intact DIAD mutation carriers and non-carriers

From: Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

  DIAD mutation non-carriers (n = 102) DIAD mutation carriers (n = 119) p value
NPI-Q Score 0.64 (1.23) 0.88 (2.19) 0.338
NPI-Q Sub-scale
 Agitation 0.07 (0.29) 0.08 (0.40) 0.699
 Anxiety 0.10 (0.35) 0.11 (0.33) 0.856
 Apathy 0.01 (0.09) 0.04 (0.27) 0.295
 Appetite 0.10 (0.41) 0.10 (0.39) 0.525
 Delusion 0.00 (0.00) 0.01 (0.09)
 Depression 0.13 (0.43) 0.13 (0.46) 0.748
 Disinhibition 0.01 (0.09) 0.03 (0.27) 0.609
 Elation 0.02 (0.13) 0.00 (0.00) 0.055
 Hallucination 0.00 (0.00) 0.00 (0.00)
 Irritability 0.12 (0.40) 0.18 (0.56) 0.207
 Motor 0.02 (0.19) 0.05 (0.28) 0.366
 Sleep changes 0.07 (0.35) 0.14 (0.47) 0.195
  1. Mixed Model with family-level random-effects, corrected for age, gender, APOE, education and family mutation type
  2. NPI-Q neuropsychiatric inventory-questionnaire