Targeting neuroplasticity in patients with neurodegenerative diseases using brain stimulation techniques

Table 1 ^aTime course of clinical effects and hypothesized therapeutic mechanisms of DBS in PD [77, 85]

Mechanism	Time after turning DBS on	PD symptom
Immediate modulation of synaptic function	Seconds	Tremor
	Seconds	Rigidity
	Minutes	Tremor
		Rigidity
		Bradykinesia
Short-term synaptic plasticity	Hours	Bradykinesia
Short-term synaptic plasticity	Hours	Axial symptoms
Long-term synaptic plasticity (functional reorganization)	Days	Axial symptoms
Long-term synaptic plasticity (functional reorganization)	Weeks	Axial symptoms

ISSN: 2047-9158