All Participants | MCI | CN | ||||
---|---|---|---|---|---|---|
Cross-sectional (MR) | β coefficient | P value | β coefficient | P value | β coefficient | P value |
CSF t-tau | 0.27 | < 0.001 | 0.29 | < 0.001 | 0.20 | < 0.001 |
CSF p-tau | 0.36 | < 0.001 | 0.33 | < 0.001 | 0.32 | < 0.001 |
CSF Aβ42 | −0.03 | 0.33 | −0.04 | 0.32 | 0.006 | 0.86 |
CSF NFL | 0.12 | < 0.001 | 0.11 | 0.04 | 0.03 | 0.45 |
Plasma NFL | 0.04 | 0.27 | 0.02 | 0.73 | −0.04 | 0.53 |
Longitudinal (MELM) | ||||||
Hippocampus | −0.008 | 0.001 | −0.007 | 0.04 | −0.003 | 0.17 |
Ventricles | 0.006 | 0.13 | 0.005 | 0.36 | 0.003 | 0.43 |
Cox (Hazard ratio) | Statistic | P value | ||||
MCI-to-AD dementia conversion | 1.53 (1.15–2.0) | 0.004 |