Fig. 5
Effect of single or combined treatment with Anle 138b and PD03 on the GCI pathology in PLP-α-syn mice. a Immunohistochemistry of pS129 to identify GCI in the brains of PLP-α-syn mice. b GCI density in the SNc of PLP-α-syn mice receiving vehicle, PD03, Anle138b or combined PD03 + Anle138b treatment. ****P < 0.0001, ***P < 0.001, **P < 0.01, one-way ANOVA followed by Bonferroni’s post-hoc test. c Linear regression analysis of correlations between GCI density in the SNc and motor disability in the challenging beam test of PLP-α-syn mice (R2 = 0.216, P = 0.003)