Fig. 2

Nigral neuronal loss and abundance of α-syn species (monomers and oligomers) in the midbrain of wild-type controls, and PLP-α-syn mice receiving vehicle or PD03 immunotherapy. a TH immunohistochemistry to define the number of dopaminergic neurons in SNc. Data are presented as mean ± SEM. One-way ANOVA with post-hoc Bonferroni test, **P < 0.01. ***P < 0.001. Scale bar, 50 μm. b Densitometric analysis of oligomeric α-synuclein in the SDS-soluble fraction. Values represent relative intensity versus control protein (β-III-tubulin). Mann-Whitney test, *P < 0.05