Skip to main content

Table 1 Sample demographics

From: Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease

Dataset AD MCI Controls Differences among three groups*
Proteomic dataset
(dataset 1, n = 411)
n = 210 n = 104 n = 97  
 Age (years), mean (SD) 77 (6.5) 75 (6.1) 72 (6.6) P = 1.13e-08
 Gender (female/male) 133/77 59/45 56/41 P = 0.4431
APOE ε4 allele (absence/presence) 89/115 58/46 65/32 P = 5.349e-04
 ROD per year, mean (SD)a −1.49 (1.26) (n = 127) NA NA NA
Brain imaging n = 53 n = 0 n = 67  
 Whole brain volume, mean (SD)b 0.66 (0.073) NA 0.69 (0.043) P = 0.003184
 Left hippocampal volume, mean (SD) b 0.0018 (0.00037) NA 0.0024
(0.00031)
P = 7.717e-15
 Right hippocampal volume, mean (SD) b 0.0019 (0.00041) NA 0.0025 (0.00031) P = 3.535e-13
 Left entorhinal cortical volume, mean (SD) b 0.00095 (0.00038) NA 0.0012 (0.00024) P = 1.433e-05
 Right entorhinal cortical volume, mean (SD) b 0.00092 (0.00034) NA 0.0013 (0.00028) P = 3.562e-08
Lipidomic dataset
(dataset 2, n = 415)
n = 185 n = 40 n = 190  
 Age (years), mean (SD) 77 (6.9) 75 (6.3) 79 (5.5) P = 6.77e-05
 Gender (female/male) 114/71 20/20 116/74 P = 0.377
APOE ε4 allele (absence/presence) 73/110 22/15 138/51 P = 8.725e-10
 ROD per year, mean (SD)a −1.50 (1.22)
(n =144)
NA NA NA
Brain imaging results n = 57 n = 8 n = 67  
 Whole brain volume, mean (SD) b 0.66 (0.071) 0.71 (0.041) 0.69 (0.098) P = 0.0006595
 Left hippocampal volume, mean (SD) b 0.0018 (0.00038) 0.0021 (0.00031) 0.0024 (0.00060) P = 1.763e-15
 Right hippocampal volume, mean (SD) b 0.0018 (0.00043) 0.0022 (0.00032) 0.0024 (0.00062) P = 2.572e-13
 Left entorhinal cortical volume, mean (SD) b 0.00093 (0.00038) 0.0012 (0.00024) 0.0012 (0.00030) P = 2.782e-06
 Right entorhinal cortical volume, mean (SD) b 0.00090 (0.00033) 0.0011 (0.00028) 0.0013 (0.00027) P = 4.114e-09
Proteomic validation dataset
(dataset 3, n = 249)
n = 94 n = 55 n = 100  
 Age (years), mean (SD) 83 (6.2) 77 (4.5) 79 (7.0) P = 2.02e-12
 Gender (female/male) 72/22 35/20 47/53 P = 1.185e-04
APOE ε4 allele (absence/presence) 40/50 30/10 79/20 P = 8.204e-07
  1. AD Alzheimer’s disease, ROD Rate of cognitive decline, SD Standard deviation, NA Not available
  2. *Differences in the means/frequencies of clinical/demographic variables were tested using ANOVA, t test or χ2 test
  3. aData of the rate of cognitive decline were available for a subset of AD patients
  4. bsMRI data were available from a subset of study participants