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Table 2 Ex vivo brain retention of [125I]RmAb158 and [125I]RmAb158-scFv8D3 (%ID/g)

From: SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Time post injection [125I]RmAb158-scFv8D3 [125I]RmAb158
2 h 1.01 ± 0.52 (n = 3) 0.13 ± 0.05 (n = 3)
72 h 0.54 ± 0.16 (n = 8) 0.24 ± 0.12 (n = 7)
144 h 0.42 ± 0.28 (n = 8) 0.15 ± 0.09 (n = 5)
336 h 0.24 ± 0.11 (n = 5) 0.13 ± 0.10 (n = 5)
648 h 0.12 ± 0.04 (n = 7) 0.05 ± 0.01 (n = 5)
  1. Data are presented as mean ± SD