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Table 2 Ex vivo brain retention of [125I]RmAb158 and [125I]RmAb158-scFv8D3 (%ID/g)

From: SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Time post injection

[125I]RmAb158-scFv8D3

[125I]RmAb158

2 h

1.01 ± 0.52 (n = 3)

0.13 ± 0.05 (n = 3)

72 h

0.54 ± 0.16 (n = 8)

0.24 ± 0.12 (n = 7)

144 h

0.42 ± 0.28 (n = 8)

0.15 ± 0.09 (n = 5)

336 h

0.24 ± 0.11 (n = 5)

0.13 ± 0.10 (n = 5)

648 h

0.12 ± 0.04 (n = 7)

0.05 ± 0.01 (n = 5)

  1. Data are presented as mean ± SD
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Translational Neurodegeneration

ISSN: 2047-9158

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