Skip to main content

Table 1 [125I]RmAb158-scFv8D3 and [125I]RmAb158 binding properties

From: SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Ligand

Target

Model

ka (M−1 s− 1)

kd (s− 1)

KD (pM)

[125I]RmAb158-scFv8D3 (n = 3)

Aβ protofibril

1:1 depletion corrected

1.96 × 105 ± 2.74 × 104

1.53 × 10− 5 ± 3.35 × 10− 6

80.7 ± 2.94

[125I]RmAb158 (n = 3)

Aβ protofibril

1:1 depletion corrected

1.84 × 105 ± 1.56 × 104

1.41 × 10− 5 ± 7.11 × 10− 6

75.1 ± 3.22

[125I]RmAb158-scFv8D3 (n = 3)

mTfR

1:1 depletion corrected

4.62 × 104 ± 8.16 × 103

7.13 × 10− 6 ± 1.67 × 10− 6

155 ± 30.6

[125I]RmAb158-scFv8D3 (n = 3)

Aβ protofibril

1:1

1.49 × 105 ± 2.76 × 104

1.12 × 10− 5 ± 1.39 × 10− 6

75.8 ± 6.05

[125I]RmAb158 (n = 3)

Aβ protofibril

1:1

1.40 × 105 ± 1.01 × 104

1.01 × 10− 5 ± 2.93 × 10− 7

71.9 ± 3.51

[125I]RmAb158-scFv8D3 (n = 3)

mTfR

1:1

3.91 × 104 ± 5.76 × 103

6.64 × 10−6 ± 2.16 × 10− 6

167 ± 37.6

  1. Kinetic parameters of LigandTracer data from [125I]RmAb158-scFv8D3 and [125I]RmAb158 interacting with Aβ protofibrils and mTfR, using a 1:1 model with and without depletion correction. Values are mean ± SD
Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us