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Table 1 [125I]RmAb158-scFv8D3 and [125I]RmAb158 binding properties

From: SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Ligand Target Model ka (M−1 s− 1) kd (s− 1) KD (pM)
[125I]RmAb158-scFv8D3 (n = 3) Aβ protofibril 1:1 depletion corrected 1.96 × 105 ± 2.74 × 104 1.53 × 10− 5 ± 3.35 × 10− 6 80.7 ± 2.94
[125I]RmAb158 (n = 3) Aβ protofibril 1:1 depletion corrected 1.84 × 105 ± 1.56 × 104 1.41 × 10− 5 ± 7.11 × 10− 6 75.1 ± 3.22
[125I]RmAb158-scFv8D3 (n = 3) mTfR 1:1 depletion corrected 4.62 × 104 ± 8.16 × 103 7.13 × 10− 6 ± 1.67 × 10− 6 155 ± 30.6
[125I]RmAb158-scFv8D3 (n = 3) Aβ protofibril 1:1 1.49 × 105 ± 2.76 × 104 1.12 × 10− 5 ± 1.39 × 10− 6 75.8 ± 6.05
[125I]RmAb158 (n = 3) Aβ protofibril 1:1 1.40 × 105 ± 1.01 × 104 1.01 × 10− 5 ± 2.93 × 10− 7 71.9 ± 3.51
[125I]RmAb158-scFv8D3 (n = 3) mTfR 1:1 3.91 × 104 ± 5.76 × 103 6.64 × 10−6 ± 2.16 × 10− 6 167 ± 37.6
  1. Kinetic parameters of LigandTracer data from [125I]RmAb158-scFv8D3 and [125I]RmAb158 interacting with Aβ protofibrils and mTfR, using a 1:1 model with and without depletion correction. Values are mean ± SD
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Translational Neurodegeneration

ISSN: 2047-9158

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