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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Fig. 5

Nuclear track emulsion (NTE) autoradiography (white puncta) detection of [125I]RmAb158-scFv8D3 (a) and [125I]RmAb158 (b) in combination with Aβ40 (green) and endothelial cell marker CD31 (red) in tg-ArcSwe mice at 3 days post injection. Scale bars, 200 μm (brain hemispheres) and 50 μm (detailed images). c Quantification of [125I]RmAb158-scFv8D3 and [125I]RmAb158 co-localization with Aβ deposits. d, e Quantification of [125I]RmAb158-scFv8D3 and [125I]RmAb158 ROI areas (d) and numbers (e) in the brain parenchyma. The quantification data were from whole hemispheres of two mice

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