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Table 1 Effects of 1,25-dihydroxyvitamin D3 exposure on gene expression in PD

From: The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Gene name Gene location Involvement in brain function Expression change
C-Ret [115] 10q11.2 Neuroprotective effects and antioxidation Up
GDNF [115] 5p13 Neuroprotective effects and antioxidation; dopaminergic neurotransmission Up
Nurr1 [116, 117] 2q22–23 DA neuronal differentiation and maturation Up
p57kip2 [116, 117] 11p15.5 DA neuronal differentiation and maturation Up
SLC30A10 [118] 2q32.3 Maintenance of homeostasis of calcium, zinc, iron and manganese Up
SLC39A2 [118] 14q11.2 Maintenance of homeostasis of calcium, zinc, iron and manganese Down
TH [119] 11p15 Dopaminergic neurotransmission Up
  1. C-Ret proto-oncogene tyrosine-protein kinase receptor Ret, GDNF glial cell-derived neurotrophic factor, TH tyrosine hydroxylase