Studies | Aims | Study cohort | Main findings | Reference |
---|---|---|---|---|
Kass-Iliyya et al. (2015) | To determine whether CCM can demonstrate small nerve fiber damage in PD. To identify relationships between CNP, IENFD and clinical features of PD. | cross-sectional (52 subjects: 26 PD, 26 controls) | CNFD was reduced but CNBD and CNFL were increased in PD compared to healthy controls. CNBD and CNFL but not CNFD correlated inversely with UPDRS-III and SCOPA-AUT. IENFD is also reduced and correlates with CNFD and motor symptoms. | [6] |
Podgorny et al. (2016) | To determine if peripheral neuropathy occurs in early untreated PD. | cross-sectional (48 subjects: 26 PD, 22 controls) | CNFL, CNBD, CNFD were reduced in PD compared to healthy controls, but CNFD didn’t have significantly difference. NCS and IENFD found no significant difference between groups. | [7] |
Misra et al. (2017) | To examine the ocular surface in patients with moderately severe PD. | cross-sectional (30 subjects: 15 PD, 15 controls) | Corneal sub-basal nerve plexus density was markedly reduced in patients with PD compared with controls. Sub-basal corneal nerve density was a significant positive correlation between ACE-R scores. | [8] |
Reddy et al. (2013) | To examine the ocular surface in patients with PSP and PD. | cross-sectional (16 subjects: 4 PD, 7 PSP, 5 controls) | There were no differences in corneal sub-basal nerve density between the 3 groups. | [31] |
Arrigo et al. (2018) | To describe corneal innervation and trigeminal alterations in drug-naive patients with PD. | cross-sectional (15 subjects: 3 PD, 12 controls) | Deep nerve tortuosity and the number of beadings were increased in patients with PD compared with controls. | [53] |
Daggumilli et al. (2019) | To evaluate the progression of corneal endothelial changes in patients with PD on long-term oral amantadine therapy. | 1-year follow-up (150 subjects: 90 PD with amantadine, 30 PD naïve amantadine, 30 controls) | SBNFLD was decreased in PD amantadine and PD amantadine naive group compared with controls after 1-year follow-up. | [54] |