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Fig. 8 | Translational Neurodegeneration

Fig. 8

From: Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

Fig. 8

Downregulated miR-18b (miR-18b-5p) signaling pathway in fALS linked SOD1 mutation. A schematic diagram illustrates that downregulated miR-18b (miR-18b-5p) by SOD1 mutation directly increases Hif1α. Mef2c is controlled by overexpressed Hif1α. Increased Mef2c is related with miR-206 expression. Mctp1 and Rarb are downregulated by increased miR-206. Intracellular Ca2+ levels is increased by downregulated Mctp1 and Neuronal differentiation is reduced by downregulated Rarb. Apoptotic cell death is induced by prohibited Ca2+ signaling and Neuronal differentiation. As a result, downregulated miR-18b-5p by SOD1 mutation leads to apoptotic cell death in fALS linked SOD1 mutation

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