TY - JOUR AU - Lagier-Tourenne, C. AU - Cleveland, D. W. PY - 2009 DA - 2009// TI - Rethinking ALS: the FUS about TDP-43 JO - Cell. VL - 136 UR - https://doi.org/10.1016/j.cell.2009.03.006 DO - 10.1016/j.cell.2009.03.006 ID - Lagier-Tourenne2009 ER - TY - JOUR AU - Ling, S. C. AU - Polymenidou, M. AU - Cleveland, D. W. PY - 2013 DA - 2013// TI - Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis JO - Neuron. VL - 79 UR - https://doi.org/10.1016/j.neuron.2013.07.033 DO - 10.1016/j.neuron.2013.07.033 ID - Ling2013 ER - TY - JOUR AU - Rosen, D. R. AU - Siddique, T. AU - Patterson, D. AU - Figlewicz, D. A. AU - Sapp, P. AU - Hentati, A. PY - 1993 DA - 1993// TI - Mutations in cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis JO - Nature. VL - 362 UR - https://doi.org/10.1038/362059a0 DO - 10.1038/362059a0 ID - Rosen1993 ER - TY - JOUR AU - Gao, F. B. AU - Almeida, S. AU - Lopez-Gonzalez, R. PY - 2017 DA - 2017// TI - Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder JO - EMBO J VL - 36 UR - https://doi.org/10.15252/embj.201797568 DO - 10.15252/embj.201797568 ID - Gao2017 ER - TY - JOUR AU - DeJesus-Hernandez, M. AU - Mackenzie, I. R. AU - Boeve, B. F. AU - Boxer, A. L. AU - Baker, M. AU - Rutherford, N. J. PY - 2011 DA - 2011// TI - Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS JO - Neuron. VL - 72 UR - https://doi.org/10.1016/j.neuron.2011.09.011 DO - 10.1016/j.neuron.2011.09.011 ID - DeJesus-Hernandez2011 ER - TY - JOUR AU - Couthouis, J. AU - Hart, M. P. AU - Erion, R. AU - King, O. D. AU - Diaz, Z. AU - Nakaya, T. PY - 2012 DA - 2012// TI - Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis JO - Hum Mol Genet VL - 21 UR - https://doi.org/10.1093/hmg/dds116 DO - 10.1093/hmg/dds116 ID - Couthouis2012 ER - TY - JOUR AU - Kwiatkowski, T. J. AU - Bosco, D. A. AU - Leclerc, A. L. AU - Tamrazian, E. AU - Vanderburg, C. R. AU - Russ, C. PY - 2009 DA - 2009// TI - Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis JO - Science. VL - 323 UR - https://doi.org/10.1126/science.1166066 DO - 10.1126/science.1166066 ID - Kwiatkowski2009 ER - TY - JOUR AU - Inukai, Y. AU - Nonaka, T. AU - Arai, T. AU - Yoshida, M. AU - Hashizume, Y. AU - Beach, T. G. PY - 2008 DA - 2008// TI - Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS JO - FEBS Lett VL - 582 UR - https://doi.org/10.1016/j.febslet.2008.07.027 DO - 10.1016/j.febslet.2008.07.027 ID - Inukai2008 ER - TY - JOUR AU - Paez-Colasante, X. AU - Figueroa-Romero, C. AU - Sakowski, S. A. AU - Goutman, S. A. AU - Feldman, E. L. PY - 2015 DA - 2015// TI - Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era JO - Nat Rev Neurol VL - 11 UR - https://doi.org/10.1038/nrneurol.2015.57 DO - 10.1038/nrneurol.2015.57 ID - Paez-Colasante2015 ER - TY - JOUR AU - Zundert, B. AU - Brown, R. H. PY - 2017 DA - 2017// TI - Silencing strategies for therapy of SOD1-mediated ALS JO - Neurosci Lett VL - 636 UR - https://doi.org/10.1016/j.neulet.2016.07.059 DO - 10.1016/j.neulet.2016.07.059 ID - Zundert2017 ER - TY - JOUR AU - Narożna, B. AU - Langwiński, W. AU - Szczepankiewicz, A. PY - 2017 DA - 2017// TI - Non-coding RNAs in pediatric airway diseases JO - Genes. VL - 8 UR - https://doi.org/10.3390/genes8120348 DO - 10.3390/genes8120348 ID - Narożna2017 ER - TY - JOUR AU - Kosik, K. S. PY - 2006 DA - 2006// TI - The neuronal microRNA system JO - Nat Rev Neurosci VL - 7 UR - https://doi.org/10.1038/nrn2037 DO - 10.1038/nrn2037 ID - Kosik2006 ER - TY - JOUR AU - Bicker, S. AU - Schratt, G. PY - 2015 DA - 2015// TI - MicroRNAs in ALS: small pieces to the puzzle JO - EMBO J VL - 34 UR - https://doi.org/10.15252/embj.201592805 DO - 10.15252/embj.201592805 ID - Bicker2015 ER - TY - JOUR AU - Russell, A. P. AU - Wada, S. AU - Vergani, L. AU - Hock, M. B. AU - Lamon, S. AU - Léger, B. PY - 2013 DA - 2013// TI - Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis JO - Neurobiol Dis VL - 49 UR - https://doi.org/10.1016/j.nbd.2012.08.015 DO - 10.1016/j.nbd.2012.08.015 ID - Russell2013 ER - TY - JOUR AU - Martí, E. AU - Pantano, L. AU - Bañez-Coronel, M. AU - Llorens, F. AU - Miñones-Moyano, E. AU - Porta, S. PY - 2010 DA - 2010// TI - A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing JO - Nucleic Acids Res VL - 38 UR - https://doi.org/10.1093/nar/gkq575 DO - 10.1093/nar/gkq575 ID - Martí2010 ER - TY - JOUR AU - Packer, A. N. AU - Xing, Y. AU - Harper, S. Q. AU - Jones, L. AU - Davidson, B. L. PY - 2008 DA - 2008// TI - The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.2390-08.2008 DO - 10.1523/JNEUROSCI.2390-08.2008 ID - Packer2008 ER - TY - JOUR AU - Hébert, S. S. AU - Horré, K. AU - Nicolaï, L. AU - Papadopoulou, A. S. AU - Mandemakers, W. AU - Silahtaroglu, A. N. PY - 2008 DA - 2008// TI - Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression JO - Proc Natl Acad Sci U S A VL - 105 UR - https://doi.org/10.1073/pnas.0710263105 DO - 10.1073/pnas.0710263105 ID - Hébert2008 ER - TY - JOUR AU - Wang, W. X. AU - Huang, Q. AU - Hu, Y. AU - Stromberg, A. J. AU - Nelson, P. T. PY - 2011 DA - 2011// TI - Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter JO - Acta Neuropathol VL - 121 UR - https://doi.org/10.1007/s00401-010-0756-0 DO - 10.1007/s00401-010-0756-0 ID - Wang2011 ER - TY - JOUR AU - Gehrke, S. AU - Imai, Y. AU - Sokol, N. AU - Lu, B. PY - 2010 DA - 2010// TI - Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression JO - Nature. VL - 466 UR - https://doi.org/10.1038/nature09191 DO - 10.1038/nature09191 ID - Gehrke2010 ER - TY - JOUR AU - Cho, H. J. AU - Liu, G. AU - Jin, S. M. AU - Parisiadou, L. AU - Xie, C. AU - Yu, J. PY - 2013 DA - 2013// TI - MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein JO - Hum Mol Genet VL - 22 UR - https://doi.org/10.1093/hmg/dds470 DO - 10.1093/hmg/dds470 ID - Cho2013 ER - TY - JOUR AU - Butovsky, O. AU - Siddiqui, S. AU - Gabriely, G. AU - Lanser, A. J. AU - Dake, B. AU - Murugaiyan, G. PY - 2012 DA - 2012// TI - Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS JO - J Clin Invest VL - 122 UR - https://doi.org/10.1172/JCI62636 DO - 10.1172/JCI62636 ID - Butovsky2012 ER - TY - JOUR AU - Koval, E. D. AU - Shaner, C. AU - Zhang, P. AU - Maine, X. AU - Fischer, K. AU - Tay, J. PY - 2013 DA - 2013// TI - Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice JO - Hum Mol Genet VL - 22 UR - https://doi.org/10.1093/hmg/ddt261 DO - 10.1093/hmg/ddt261 ID - Koval2013 ER - TY - JOUR AU - Han, J. AU - Pedersen, J. S. AU - Kwon, S. C. AU - Belair, C. D. AU - Kim, Y. K. AU - Yeom, K. H. PY - 2009 DA - 2009// TI - Posttranscriptional crossregulation between Drosha and DGCR8 JO - Cell. VL - 136 UR - https://doi.org/10.1016/j.cell.2008.10.053 DO - 10.1016/j.cell.2008.10.053 ID - Han2009 ER - TY - JOUR AU - Lee, Y. AU - Ahn, C. AU - Han, J. AU - Choi, H. AU - Kim, J. AU - Yim, J. PY - 2003 DA - 2003// TI - The nuclear RNase III Drosha initiates microRNA processing JO - Nature. VL - 425 UR - https://doi.org/10.1038/nature01957 DO - 10.1038/nature01957 ID - Lee2003 ER - TY - JOUR AU - Diederichs, S. AU - Haber, D. A. PY - 2007 DA - 2007// TI - Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression JO - Cell. VL - 131 UR - https://doi.org/10.1016/j.cell.2007.10.032 DO - 10.1016/j.cell.2007.10.032 ID - Diederichs2007 ER - TY - JOUR AU - Chen, Z. AU - Li, Y. AU - Zhang, H. AU - Huang, P. AU - Luthra, R. PY - 2010 DA - 2010// TI - Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression JO - Oncogene. VL - 29 UR - https://doi.org/10.1038/onc.2010.193 DO - 10.1038/onc.2010.193 ID - Chen2010 ER - TY - JOUR AU - Choi, E. AU - Cha, M. J. AU - Hwang, K. C. PY - 2014 DA - 2014// TI - Roles of calcium regulating MicroRNAs in cardiac ischemia-reperfusion injury JO - Cells. VL - 3 UR - https://doi.org/10.3390/cells3030899 DO - 10.3390/cells3030899 ID - Choi2014 ER - TY - JOUR AU - Makeyev, E. V. AU - Zhang, J. AU - Carrasco, M. A. AU - Maniatis, T. PY - 2007 DA - 2007// TI - The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing JO - Mol Cell VL - 27 UR - https://doi.org/10.1016/j.molcel.2007.07.015 DO - 10.1016/j.molcel.2007.07.015 ID - Makeyev2007 ER - TY - JOUR AU - Berridge, M. J. AU - Bootman, M. D. AU - Lipp, P. PY - 1998 DA - 1998// TI - Calcium--a life and death signal JO - Nature. VL - 395 UR - https://doi.org/10.1038/27094 DO - 10.1038/27094 ID - Berridge1998 ER - TY - STD TI - Qiu L, Yu H, Liang F. Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress. J Neurochem. 2015. https://doi.org/10.1111/jnc.13251. ID - ref30 ER - TY - JOUR AU - Shin, O. H. AU - Han, W. AU - Wang, Y. AU - Südhof, T. C. PY - 2005 DA - 2005// TI - Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M407305200 DO - 10.1074/jbc.M407305200 ID - Shin2005 ER - TY - JOUR AU - Tradewell, M. L. AU - Cooper, L. A. AU - Minotti, S. AU - Durham, H. D. PY - 2011 DA - 2011// TI - Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention JO - Neurobiol Dis VL - 42 UR - https://doi.org/10.1016/j.nbd.2011.01.016 DO - 10.1016/j.nbd.2011.01.016 ID - Tradewell2011 ER - TY - JOUR AU - Mangelsdorf, D. J. AU - Thummel, C. AU - Beato, M. AU - Herrlich, P. AU - Schütz, G. AU - Umesono, K. PY - 1995 DA - 1995// TI - The nuclear receptor superfamily: the second decade JO - Cell. VL - 83 UR - https://doi.org/10.1016/0092-8674(95)90199-X DO - 10.1016/0092-8674(95)90199-X ID - Mangelsdorf1995 ER - TY - JOUR AU - Li, Y. AU - Dawson, M. I. AU - Agadir, A. AU - Lee, M. O. AU - Jong, L. AU - Hobbs, P. D. PY - 1998 DA - 1998// TI - Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction JO - Int J Cancer VL - 75 UR - https://doi.org/3.0.CO;2-9 DO - 3.0.CO;2-9 ID - Li1998 ER - TY - JOUR AU - Pinto, C. AU - Cárdenas, P. AU - Osses, N. AU - Henríquez, J. P. PY - 2013 DA - 2013// TI - Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis JO - Front Cell Neurosci VL - 7 UR - https://doi.org/10.3389/fncel.2013.00239 DO - 10.3389/fncel.2013.00239 ID - Pinto2013 ER - TY - JOUR AU - Liang, Y. AU - Mirnics, Z. K. AU - Yan, C. AU - Nylander, K. D. AU - Schor, N. F. PY - 2003 DA - 2003// TI - Bcl-2 mediates induction of neural differentiation JO - Oncogene. VL - 22 UR - https://doi.org/10.1038/sj.onc.1206844 DO - 10.1038/sj.onc.1206844 ID - Liang2003 ER - TY - JOUR AU - Kruman, I. I. AU - Pedersen, W. A. AU - Springer, J. E. AU - Mattson, M. P. PY - 1999 DA - 1999// TI - ALS-linked cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis JO - Exp Neurol VL - 160 UR - https://doi.org/10.1006/exnr.1999.7190 DO - 10.1006/exnr.1999.7190 ID - Kruman1999 ER - TY - JOUR AU - Pinton, P. AU - Ferrari, D. AU - Rapizzi, E. AU - Virgilio, F. AU - Pozzan, T. AU - Rizzuto, R. PY - 2001 DA - 2001// TI - The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action JO - EMBO J VL - 20 UR - https://doi.org/10.1093/emboj/20.11.2690 DO - 10.1093/emboj/20.11.2690 ID - Pinton2001 ER - TY - JOUR AU - Park, J. H. AU - Park, H. S. AU - Hong, S. AU - Kang, S. PY - 2016 DA - 2016// TI - Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS JO - Exp Mol Med VL - 48 ID - Park2016 ER - TY - JOUR AU - Chen, H. AU - Qian, K. AU - Du, Z. AU - Cao, J. AU - Petersen, A. AU - Liu, H. PY - 2014 DA - 2014// TI - Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons JO - Cell Stem Cell VL - 14 UR - https://doi.org/10.1016/j.stem.2014.02.004 DO - 10.1016/j.stem.2014.02.004 ID - Chen2014 ER - TY - JOUR AU - Reynolds, B. A. AU - Weiss, S. PY - 1992 DA - 1992// TI - Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system JO - Science. VL - 255 UR - https://doi.org/10.1126/science.1553558 DO - 10.1126/science.1553558 ID - Reynolds1992 ER - TY - JOUR AU - Im, W. AU - Ban, J. J. AU - Chung, J. Y. AU - Lee, S. T. AU - Chu, K. AU - Kim, M. PY - 2015 DA - 2015// TI - Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model JO - Sci Rep VL - 5 UR - https://doi.org/10.1038/srep16887 DO - 10.1038/srep16887 ID - Im2015 ER - TY - JOUR AU - Cho, M. S. AU - Hwang, D. Y. AU - Kim, D. W. PY - 2008 DA - 2008// TI - Efficient derivation of functional dopaminergic neurons from human embryonic stem cells on a large scale JO - Nat Protoc VL - 3 UR - https://doi.org/10.1038/nprot.2008.188 DO - 10.1038/nprot.2008.188 ID - Cho2008 ER - TY - JOUR AU - Corti, S. AU - Nizzardo, M. AU - Nardini, M. AU - Donadoni, C. AU - Salani, S. AU - Ronchi, D. PY - 2010 DA - 2010// TI - Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice JO - Brain. VL - 133 UR - https://doi.org/10.1093/brain/awp318 DO - 10.1093/brain/awp318 ID - Corti2010 ER - TY - JOUR AU - Peters, O. M. AU - Ghasemi, M. AU - Brown, R. H. PY - 2015 DA - 2015// TI - Emerging mechanisms of molecular pathology in ALS JO - J Clin Invest VL - 125 UR - https://doi.org/10.1172/JCI71601 DO - 10.1172/JCI71601 ID - Peters2015 ER - TY - JOUR AU - Ha, M. AU - Kim, V. N. PY - 2014 DA - 2014// TI - Regulation of microRNA biogenesis JO - Nat Rev Mol Cell Biol VL - 15 UR - https://doi.org/10.1038/nrm3838 DO - 10.1038/nrm3838 ID - Ha2014 ER - TY - JOUR AU - Kim, K. Y. AU - Hwang, Y. J. AU - Jung, M. K. AU - Choe, J. AU - Kim, Y. AU - Kim, S. PY - 2014 DA - 2014// TI - A multifunctional protein EWS regulates the expression of Drosha and microRNAs JO - Cell Death Differ VL - 21 UR - https://doi.org/10.1038/cdd.2013.144 DO - 10.1038/cdd.2013.144 ID - Kim2014 ER - TY - JOUR AU - Krishnan, J. AU - Ahuja, P. AU - Bodenmann, S. AU - Knapik, D. AU - Perriard, E. AU - Krek, W. PY - 2008 DA - 2008// TI - Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function JO - Circ Res VL - 103 UR - https://doi.org/10.1161/01.RES.0000338613.89841.c1 DO - 10.1161/01.RES.0000338613.89841.c1 ID - Krishnan2008 ER - TY - JOUR AU - Rao, P. K. AU - Kumar, R. M. AU - Farkhondeh, M. AU - Baskerville, S. AU - Lodish, H. F. PY - 2006 DA - 2006// TI - Myogenic factors that regulate expression of muscle-specific microRNAs JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0602831103 DO - 10.1073/pnas.0602831103 ID - Rao2006 ER - TY - JOUR AU - Dolt, K. S. AU - Mishra, M. K. AU - Karar, J. AU - Baig, M. A. AU - Ahmed, Z. AU - Pasha, M. A. PY - 2007 DA - 2007// TI - cDNA cloning, gene organization and variant specific expression of HIF-1 alpha in high altitude yak (Bos grunniens) JO - Gene. VL - 386 UR - https://doi.org/10.1016/j.gene.2006.08.004 DO - 10.1016/j.gene.2006.08.004 ID - Dolt2007 ER - TY - JOUR AU - Pasinelli, P. AU - Brown, R. H. PY - 2006 DA - 2006// TI - Molecular biology of amyotrophic lateral sclerosis: insights from genetics JO - Nat Rev Neurosci VL - 7 UR - https://doi.org/10.1038/nrn1971 DO - 10.1038/nrn1971 ID - Pasinelli2006 ER - TY - JOUR AU - Kim, K. Y. AU - Lee, H. W. AU - Shim, Y. M. AU - Mook-Jung, I. AU - Jeon, G. S. AU - Sung, J. J. PY - 2015 DA - 2015// TI - A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells JO - Biochem Biophys Res Commun VL - 464 UR - https://doi.org/10.1016/j.bbrc.2015.06.125 DO - 10.1016/j.bbrc.2015.06.125 ID - Kim2015 ER - TY - JOUR AU - Mackenzie, I. R. AU - Rademakers, R. AU - Neumann, M. PY - 2010 DA - 2010// TI - TDP-43 and FUS in amyotrophic lateralsclerosis and frontotemporal dementia JO - Lancet Neurol VL - 9 UR - https://doi.org/10.1016/S1474-4422(10)70195-2 DO - 10.1016/S1474-4422(10)70195-2 ID - Mackenzie2010 ER - TY - JOUR AU - Yamazaki, M. AU - Esumi, E. AU - Nakano, I. PY - 2005 DA - 2005// TI - Is motoneuronal cell death in amyotrophic lateral sclerosis apoptosis? JO - Neuropathology. VL - 25 UR - https://doi.org/10.1111/j.1440-1789.2005.00648.x DO - 10.1111/j.1440-1789.2005.00648.x ID - Yamazaki2005 ER - TY - JOUR AU - Taylor, J. P. AU - Brown, R. H. AU - Cleveland, D. W. PY - 2016 DA - 2016// TI - Decoding ALS: from genes to mechanism JO - Nature. VL - 539 UR - https://doi.org/10.1038/nature20413 DO - 10.1038/nature20413 ID - Taylor2016 ER -