Fig. 4

Relationships among altered network metrics, biomarkers and neuropsycholohical performance. a The scores on the LM-immediate were negatively associated with nodal local efficiency of the DCG.L (r = − 0.303, P = 0.015) in the HC group; b and c The scores on the LM-immediate were negatively associated with nodal global efficiency of the SFGdor.R (r = − 0.279, P = 0.023) (b) and the SFGmed.L (r = − 0.294, P = 0.017) (c) in the SCD group; d, e and f The CSF Aβ1–42 was negatively related to the nodal strength of PHG.L (r = − 0.671, P = 0.024) (d), nodal global efficiency of the TPOsup.R (r = − 0.642, P = 0.033) (e) and nodal local efficiency of the IFGoperc.R (r = − 0.654, P = 0.029) (f) in the SCD group; g The scores on the CCI were positively associated with nodal global efficiency of the TPOsup.L (r = 0.297, P = 0.016) in the SCD group. Abbreviations: HC, healthy control; SCD, subjective cognitive decline; DCG.L, left median cingulate and paracingulate gyri; SFGdor.R, right dorsolateral superior frontal gyrus; SFGmed.L, left medial superior frontal gyrus; PHG.L, left parahippocampal gyrus; TPOsup.R, right temporal pole-superior temporal gyrus; IFGoperc.R, right inferior frontal gyrus-opercular part; CSF, cerebrospinal fluid; Aβ, amyloid-β; TPOsup.L, left temporal pole-superior temporal gyrus; LM, Logical Memory; CCI, cognitive change index