Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

Remnestål, Julia; Öijerstedt, Linn; Ullgren, Abbe; Olofsson, Jennie; Bergström, Sofia; Kultima, Kim; Ingelsson, Martin; Kilander, Lena; Uhlén, Mathias; Månberg, Anna; Graff, Caroline; Nilsson, Peter

doi:10.1186/s40035-020-00198-y

Translational Neurodegeneration

Table 2 List of proteins with significant differences in protein profiles. Sorted by p-values for comparison of bvFTD and NC (lowest to highest)

From: Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

Protein name	Short name	Uniprot ID	Antibody	bvFTD vs NC	bvFTD vs PMC	FTD vs unaffected	Direction of change^c
Neurosecretory protein VGF	VGF	O15240	HPA055177	0.0002	0.0003	0.0001^b	↓
Tenascin-R	TN-R	Q92752	HPA027150	0.0008	0.002	0.0007^b	↑
Neuronal pentraxin receptor	NPTXR	O95502	HPA001079	0.003	0.008	0.0005^b	↓
Transmembrane protein 132D	TMEM132D	Q14C87	HPA010739	0.003	0.008	0.0007	↓
Prodynorphin	PDYN	P01213	HPA053342	0.003	0.006	0.0007^b	↓
Neurocan core protein	NCAN	O14594	HPA058000	0.003	0.006	0.0007^b	↓
Calsyntenin-1	CLSTN1	O94985	HPA012749^a	0.003	0.01	0.0009^b	↓
Cadherin-8	CDH8	P55286	HPA014908	0.003	0.01	0.001	↓
Neural cell adhesion molecule L1-like protein	CHL1	O00533	HPA003345	0.003	0.02	0.003^b	↓
Rabphilin-3A	RPH3A	Q9Y2J0	HPA002475	0.004	0.01	0.001	↓
Peptidyl-glycine alpha-amidating monooxygenase	PAM	P19021	HPA042260^a	0.004	0.02	0.005^b	↓
Neuronal pentraxin-1	NP1	Q15818	HPA077062	0.006	0.02	0.0007	↓
von Willebrand factor C domain-containing protein 2-like	VWC2L	B2RUY7	HPA059414	0.006	0.01	0.003	↑
Tripeptidyl-peptidase 1	TPP-1	O14773	HPA037709	0.008	0.02	0.002	↑
Amyloid-like protein 1	APLP-1	P51693	HPA028971	0.008	0.05	0.009	↓
Apolipoprotein A-I	ApoA-I	P02647	HPA046715^a	0.01	0.04	0.001	↑
Neurofilament medium polypeptide	NF-M	P07197	HPA022845	0.02	0.02	0.0007^b	↑
Neurofilament medium polypeptide	NF-M	P07197	HPA023138	0.02	0.02	0.0008^b	↑
Leucine-rich alpha-2-glycoprotein	LRG	P02750	HPA001888^a	0.02	0.03	0.002	↑
Alpha-1-antichymotrypsin	ACT	P01011	HPA000893^a	0.02	0.03	0.003	↑
UPF0606 protein KIAA1549L	KIAA1549L	Q6ZVL6	HPA051594	0.02	0.02	0.005	↓
Inter-alpha-trypsin inhibitor heavy chain H1	ITI-HC1	P19827	HPA042049^a	0.02	0.03	0.005	↑
Oligodendrocyte-myelin glycoprotein	OMG	P23515	HPA008206^a	0.02	0.02	0.006^b	↓
Neuronal cell adhesion molecule	Nr-CAM	Q92823	HPA061433	0.02	0.02	0.006	↓
TAR DNA-binding protein 43	TDP-43	Q13148	HPA070770	0.02	0.01	0.006	↑
Brevican core protein	BEHAB	Q96GW7	HPA007865	0.06	0.02	0.008	↓
Phosphoinositide-3-kinase-interacting protein 1	PIK3IP1	Q96FE7	HPA007353^a	0.08	0.04	0.009	↓

P-values (FDR adjusted) based on Mann Whitney U tests for each statistically significant sub group comparison. Group comparisons with PPA (PPA vs NC, PPA vs PMC and PPA vs bvFTD) and between unaffected (NC vs PMC) were not statistically significant
^a The generalized linear model showed a significant (p < 0.05) age effect
^b The result could be replicated in the second cohort
^c Direction of change in FTD compared to unaffected individuals

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ISSN: 2047-9158

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