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Table 2 List of proteins with significant differences in protein profiles. Sorted by p-values for comparison of bvFTD and NC (lowest to highest)

From: Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

Protein nameShort nameUniprot IDAntibodybvFTD vs NCbvFTD vs PMCFTD vs unaffectedDirection of changec
Neurosecretory protein VGFVGFO15240HPA0551770.00020.00030.0001b
Tenascin-RTN-RQ92752HPA0271500.00080.0020.0007b
Neuronal pentraxin receptorNPTXRO95502HPA0010790.0030.0080.0005b
Transmembrane protein 132DTMEM132DQ14C87HPA0107390.0030.0080.0007
ProdynorphinPDYNP01213HPA0533420.0030.0060.0007b
Neurocan core proteinNCANO14594HPA0580000.0030.0060.0007b
Calsyntenin-1CLSTN1O94985HPA012749a0.0030.010.0009b
Cadherin-8CDH8P55286HPA0149080.0030.010.001
Neural cell adhesion molecule L1-like proteinCHL1O00533HPA0033450.0030.020.003b
Rabphilin-3ARPH3AQ9Y2J0HPA0024750.0040.010.001
Peptidyl-glycine alpha-amidating monooxygenasePAMP19021HPA042260a0.0040.020.005b
Neuronal pentraxin-1NP1Q15818HPA0770620.0060.020.0007
von Willebrand factor C domain-containing protein 2-likeVWC2LB2RUY7HPA0594140.0060.010.003
Tripeptidyl-peptidase 1TPP-1O14773HPA0377090.0080.020.002
Amyloid-like protein 1APLP-1P51693HPA0289710.0080.050.009
Apolipoprotein A-IApoA-IP02647HPA046715a0.010.040.001
Neurofilament medium polypeptideNF-MP07197HPA0228450.020.020.0007b
Neurofilament medium polypeptideNF-MP07197HPA0231380.020.020.0008b
Leucine-rich alpha-2-glycoproteinLRGP02750HPA001888a0.020.030.002
Alpha-1-antichymotrypsinACTP01011HPA000893a0.020.030.003
UPF0606 protein KIAA1549LKIAA1549LQ6ZVL6HPA0515940.020.020.005
Inter-alpha-trypsin inhibitor heavy chain H1ITI-HC1P19827HPA042049a0.020.030.005
Oligodendrocyte-myelin glycoproteinOMGP23515HPA008206a0.020.020.006b
Neuronal cell adhesion moleculeNr-CAMQ92823HPA0614330.020.020.006
TAR DNA-binding protein 43TDP-43Q13148HPA0707700.020.010.006
Brevican core proteinBEHABQ96GW7HPA0078650.060.020.008
Phosphoinositide-3-kinase-interacting protein 1PIK3IP1Q96FE7HPA007353a0.080.040.009
  1. P-values (FDR adjusted) based on Mann Whitney U tests for each statistically significant sub group comparison. Group comparisons with PPA (PPA vs NC, PPA vs PMC and PPA vs bvFTD) and between unaffected (NC vs PMC) were not statistically significant
  2. a The generalized linear model showed a significant (p < 0.05) age effect
  3. b The result could be replicated in the second cohort
  4. c Direction of change in FTD compared to unaffected individuals