Fig. 1From: The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseasesStructure of V-ATPases. V-ATPase is composed of multiple core subunits and two accessory proteins. The cytosolic V1 domain includes eight different subunits (A, B, C, D, E, F, G, and H) and the integral V0 domain contains six different subunits (a, c, c’, c”, d, and e). The hypothetic positions of the ATP6AP1/Ac45 and ATP6AP2/PRR are includedBack to article page