Skip to main content
Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice

Fig. 3

Paroxetine treatment restores glutamate receptor subunit of GluN2A levels and NMDAR function decreased in AD mice. a WBs of glutamate receptor subunits (GluN2A, GluN2B, GluN1, GluA1 and GluA2) in cortical homogenates are shown. The left panel shows representative western blots and the right panel shows quantification of WBs. n = 3 mice for per group. Data are presented as mean ± SEM. * P < 0.05; unpaired t-test. b Representative traces of AMPAR EPSCs recorded at − 70 mV and NMDAR EPSC at + 40 mV. Scale bar: 400pA (vertical) × 100 ms (horizontal). n = 9–16 neurons from 3 to 5 mice for per group (left panel). Ratio of NMDAR/AMPAR in cortex was quantified respectively for per group (Right panel). Data are presented as mean ± SEM. * P < 0.05; two-way ANOVA with Sidak’s multiple comparison post hoc test

Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us