CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

Table 3 Logistic regression analysis of multiple CSF biomarkers

Ctrl Group
	Predictors	OR (95% CI)	Accuracy of model	P
Asymptomatic carriers	t-α-syn o-α-syn TNF-α	0.997 (0.994–0.999) 1.029 (0.999–1.060) 1.418 (0.998–2.014)	AUC: 0.843 (0.724–0.961) Sens: 87.5%, Spec: 66.7%	0.000
PD (i.e. sPD & symptomatic LRRK2 mutation carriers)	t-α-syn o-α-syn pS129-α-syn IL-16	0.996 (0.994–0.999) 1.031 (1.005–1.056) 1.035 (1.010–1.059) 0.785 (0.60–1.022)	AUC: 0.896 (0.823–0.969) Sens: 87.0% Spec: 78.6%	0.000

AUC area under the curve, HC Healthy controls, NPV negative predictive value, OR odds ratio, o-α-syn oligomeric α-synuclein, PD sporadic and symptomatic LRRK2 mutation patients, PPV positive predictive value; pSer129-α-synuclein, phosphorylated α-synuclein protein at serine 129, Sens sensitivity, Spec specificity, TNF-α tumor necrosis factor-alpha, t-α-syn total α-synuclein