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Table 3 Logistic regression analysis of multiple CSF biomarkers

From: CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

Ctrl Group
 PredictorsOR (95% CI)Accuracy of modelP
Asymptomatic carrierst-α-syn
o-α-syn
TNF-α
0.997 (0.994–0.999)
1.029 (0.999–1.060)
1.418 (0.998–2.014)
AUC: 0.843 (0.724–0.961)
Sens: 87.5%,
Spec: 66.7%
0.000
PD (i.e. sPD & symptomatic LRRK2 mutation carriers)t-α-syn
o-α-syn
pS129-α-syn
IL-16
0.996 (0.994–0.999)
1.031 (1.005–1.056)
1.035 (1.010–1.059)
0.785 (0.60–1.022)
AUC: 0.896 (0.823–0.969)
Sens: 87.0%
Spec: 78.6%
0.000
  1. AUC area under the curve, HC Healthy controls, NPV negative predictive value, OR odds ratio, o-α-syn oligomeric α-synuclein, PD sporadic and symptomatic LRRK2 mutation patients, PPV positive predictive value; pSer129-α-synuclein, phosphorylated α-synuclein protein at serine 129, Sens sensitivity, Spec specificity, TNF-α tumor necrosis factor-alpha, t-α-syn total α-synuclein