Fig. 1

Box-and-whiskers plots of CSF levels of α-syn forms in sPD, symptomatic and asymptomatic LRRK2 mutation carriers, and Ctrl. Box-and-whiskers plots of CSF levels of α-syn species in sPD, asymptomatic LRRK2 carriers, symptomatic LRRK2 carriers and Ctrls. a CSF levels of t-α-syn, b CSF levels of o-α-syn, c CSF levels of pSer129-α-syn, d ratio of o-α-syn/ t-α-syn %, e ratio of pSer129-α-syn/ t-α-syn %. The line through the middle of the boxes corresponds to the median and the lower and the upper lines to the 25th and 75th percentiles, respectively. The whiskers extend from the 5th percentile on the bottom to the 95th percentile on top. Differences between groups were assessed with the GLM compared to Ctrl group and adjusted for age and gender. *P < 0.05, **P < 0.01, ***P < 0.001