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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Fig. 1

Diagram of the potential seeding-conversion mechanism of α-synuclein during the RT-QuIC. The seed (in red) triggers the aggregation of monomeric α-synuclein (substrate, in green). The conversion causes the conformational modification into misfolded oligomers (blue) that elongate into fibrils. After the detection of fibrils, a quaking event breaks the longer fibrils into shorter, reactive oligomers, which further seed the conversion of monomeric α-synuclein (modified from [92]). The classical shape of the kinetic curve is shown within the aggregation process

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Translational Neurodegeneration

ISSN: 2047-9158

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