Lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1–40 and cerebral vulnerability in normal aging

Table 2 Significant correlations between decreased serum levels of miR-181c-5p and lower cortical glucose uptake measured by FDG-PET

Cortical region	CS (mm²)	r	P
L insula	3891	0.29	10⁻⁴
L entorhinal	1588	0.3	10⁻⁵
L superior parietal	431	0.39	10⁻⁴
L superior frontal	245	0.31	10⁻³
L anterior cingulate	174	0.33	10⁻⁴
R inferior parietal	1531	0.38	10⁻⁶
R insula	839	0.37	10⁻⁵
R medial orbitofrontal	819	0.34	10⁻⁴
R superior parietal	583	0.35	10⁻⁶
R lingual gyrus	160	0.39	10⁻⁴
R precuneus	144	0.37	10⁻⁶

CS Cluster size; it refers to the extent of significant correlation between serum levels of miR-181c-5p and cortical glucose uptake. L Left and R Right cortical hemisphere. Regression analyses were adjusted by age and sex. r: Pearson correlation coefficient; p: exact p-value (corrected for multiple comparisons)

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