Fig. 2

Vertex-wise regression analysis, adjusted by age and sex, to evaluate correlations between serum levels of miR-181c-5p and cortical glucose metabolism, measured with FDG-PET. a Significant patterns of correlations were represented on inflated cortical surfaces (L, left; R, right). Color bars represent corrected p-values (p < 0.05) using a hierarchical approach based on sequential statistical thresholding [35]. b Significant patterns of correlations displayed on flattened cortical surfaces. Squares with colored borders limit the location of significant regional changes. c The surface of the square was zoomed on flattened cortical maps displaying cytoarchitectonic delimitation of affected regions [36,37,38,39,40]