Fig. 5
Small IBA-1+ cells number increase in hippocampus of APP/PS1 mice treated with BM-M. a, b Representative IBA-1 immunostaining comparison between PBS injected mice (Control) and BM-M treated mice. c-e Small IBA-1 microglia cells, medium sized cluster of microglia (cluster I) and large sized clusters of microglia number per mm2 in cortex, hippocampus and brainstem comparison between control and BM-M treated mice showing an increase of small microglia cells in the hippocampus of treated mice. f-h Representative images of different microglia sizes and clusters co-stained with Aβ[37-42] plaques showing clusters of microglia around plaques and small microglia cells not associated Aβ. Bar graphs display the mean ± SEM (error bars) (*p < 0.05)