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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Fig. 4

Predicted overlap (yellow) of aSyn in PD (green) with deposition patterns for tau in Alzheimer’s disease and primary age-related tauopathy (red) in the brainstem, limbic (e.g. amygdala, hippocampus, anterior cingulate) and subcortical areas (e.g. basal ganglia) and neocortical areas. According to the Braak stages of neurofibrillary tau pathology [98] the deposition of tau follows a similar involvement of anatomical systems (i.e., brainstem to limbic/subcortical to neocortex) as seen for aSyn for Lewy pathology [97]

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