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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Fig. 3

Predicted overlap (yellow) of aSyn in PD (green) with deposition patterns for amyloid-β in Alezheimer’s disease (red) in the brainstem, limbic (e.g. amygdala, hippocampus, anterior cingulate) and subcortical areas (e.g. basal ganglia) and neocortical areas. According to the Thal Phases the deposition of amyloid-β follows a neocortical to limbic/subcortical to brainstem path [102], which is opposite to that seen for aSyn according to the Braak stages of Lewy pathology [97]

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