Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies

Table 3 Neurodegenerative processes-related genes among the target output from the differentially expressed miRNAs

Input Gene	Input miRNA	Start	Stop	Computational Predictions	Confirmed Predictions
ADAM10	hsa-let-7i-5p	783	801	Miranda	0
	hsa-miR-23a-3p	1477	1499	Miranda	0
	hsa-miR-451a	3640	3660	Miranda	0
AKT1	hsa-miR-451a	60	79	Miranda	Mirtarbase
APP	hsa-let-7i-5p	532	553	Miranda	0
APPBP2	hsa-let-7i-5p	3533	3553	Miranda	0
	hsa-miR-151a-3p	1868	1888	Miranda	0
	hsa-miR-21-5p	4099	4120	Miranda	0
BCL2	hsa-miR-126-3p	4169	4192	Miranda	0
BCL2	hsa-miR-23a-3p	4400	4418	Miranda	0
CASP2	hsa-let-7i-5p	2265	2285	Miranda	0
CASP2	hsa-miR-151a-3p	2025	2045	Miranda	0
CASP3	hsa-let-7i-5p	141	160	Miranda	0
CASP3	hsa-miR-23a-3p	808	828	Miranda	0
CASP8	hsa-miR-21-5p	867	888	Miranda	0
CASP8	hsa-let-7i-5p	118	139	Miranda	0
CASP10	hsa-miR-23a-3p	2104	2124	Miranda	0
CASP14	hsa-let-7i-5p	56	77	Miranda	0
CCNE2	hsa-miR-126-3p	1212	1233	Miranda	Mirtarbase
	hsa-miR-151a-3p	249	270	Miranda	0
	hsa-let-7i-5p	350	370	Miranda	0
COX6B2	hsa-let-7i-5p	69	91	Miranda	0
COX6C	hsa-miR-21-5p	312	332	Miranda	0
COX7A1	hsa-let-7i-5p	49	54	Rnahybrid	0
COX7B	hsa-let-7i-5p	301	321	Miranda	0
COX7B	hsa-miR-23a-3p	832	852	Miranda	0
COX11	hsa-miR-151a-3p	1584	1604	Miranda	0
GSK3B	hsa-miR-21-5p	912	934	Miranda	0
	hsa-let-7i-5p	320	342	Miranda	0
	hsa-miR-21-5p	5125	5147	Miranda	0
	hsa-miR-23a-3p	988	1008	Miranda	0
MIF	hsa-miR-451a	90	109	Miranda	Mirtarbase\|OncomiRDB\|
UBE2J1	hsa-miR-23a-3p	1920	1942	Miranda	0
UBE2G2	hsa-let-7i-5p	251	272	Miranda	0
UBE2L3	hsa-miR-451a	322	343	Miranda	0
UBE2L3	hsa-miR-23a-3p	1188	1209	Miranda	0

MirGate results for Computational and (when possible) Confirmed target genes are shown (in alphabetical order). The name of the prediction tool reporting each target gene is indicated. “0” means no confirmation was found in the analysis for that specific target. Start and Stop indicate the miRNA binding site (beginning and ending nucleotide) in the targeted gene sequence. Key: ADAM10 ADAM Metallopeptidase Domain 10), APP, β-amyloid precursor), APPBP2 Amyloid protein-binding protein 2, GSK3B Glycogen synthase kinase 3, AKT1 RAC-alpha serine/ threonine-protein kinase, CAB39 Calcium binding protein 39, CASP Caspase, CCNE Cyclin E, COX Cytochrome c oxidase, MIF Macrophage migration inhibitory factor, UBE2 Ubiquitin Conjugating enzyme E2

ISSN: 2047-9158