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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

Fig. 4

Regional regression analysis between CSF-KLK6 and the regional C/vPiB-PET uptake signal. Voxel based regional regression analysis between CSF-KLK6 levels and the cerebral C/vPiB-PET signal, controlled for copies of the ApoE ɛ4 allele. Significant (p < 0.05 FDR corrected) negative correlations are depicted in red to yellow (increasing T values) and are projected on axial T1 MRI scans (average of 152 scans, implemented in SPM12), numbers indicate z-coordinates of slices in Talairach space in mm. CSF: cerebrospinal fluid; KLK: kallikrein-related peptidase, ApoE ɛ4: apolipoprotein E epsilon 4; C/vPiB-PET: Cerebrum to vermis Pittsburgh Compound B-positron emission tomography

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