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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

Fig. 2

ROC curves of KLK6, KLK8 and KLK10 in CSF between patients with AD and NCs. a ROC graph with AUC of KLK6, KLK8 and KLK10 in the CSF between patients with AD and NCs. AUCs were 0.788 (95%-confidence interval (CI) 0.667–0.910) for KLK6, 0.634 (95%-CI 0.471–0.797) for KLK8, and 0.692 (95%-CI 0.552–0.833) for KLK10, respectively. The best cut-off of 270 ng/l for KLK6 had a sensitivity of 66% and a specificity of 87% (LRAD = 7.58, LRNC = 0.39). For KLK8 the best cut-off was 0.145 ng/l (sensitivity 72%, specificity 57%, LRAD = 1.67, LRNC = 0.49) and for KLK10 0.575 ng/l (sensitivity 66%, specificity 65%, LRAD = 1.89, LRNC = 0.52). b ROC graph with AUC of KLK6, KLK8 and KLK10 in the CSF between patients with AD (A+/T+/N+) and patients with AD (A+/T−/N+) combined with NC. AUCs were 0.922 (95%-CI 0.855–0.988) for KLK6, 0.591 (95%-CI 0.441–0.741) for KLK8, and 0.679 (95%-CI 0.533–0.826) for KLK10, respectively. The best cut-off was 270 ng/l for KLK6 (sensitivity 86%, specificity 83%, LRAD A + T + N+ = 5.06, LRNC&AD + A + T-N+ = 0.17). The best cut-off for KLK8 was 0.155 ng/L (sensitivity 71%, specificity 56%, LRAD A + T + N+ = 1.61, LRNC&AD + A + T-N+ = 0.52) and for KLK10 (sensitivity 62%, specificity 77%, LRAD A + T + N+ = 2.70, LRNC&AD + A + T-N+ = 0.49). ROC: receiver operating characteristics, AUC: area under the curve

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