Fig. 4From: Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1HUMSCs transplantation alleviated Purkinje cell damage SCA1 mice. Damages to the Purkinje cells in the SCA1 mice were assessed by sacrificing six-month-old SCA1 mice and observing, under optical microscope, Purkinje cells in lobules III and VI in tissue slices following immunohistochemical staining with anti-calbindin antibodies. Presented are representative photomicrographs of tissue slices of lobules III (a1 and a2) and VI (a3 and a4) in mice at 6 months of age in all groups. Purkinje cell number per unit length (b and d) and cell body area (c and e) in lobules III and VI were quantified. At 6 months of age, significant decreases were observed in both cell number and cell body area in the groups of SCA1 and SCA1-PBS. Transplantation of HUMSCs salvaged such losses (b-e). * p < 0.05 compared with the Normal group. ▲ p < 0.05 compared with the Normal-PBS group. # p < 0.05 compared with the SCA1-HUMSCs groupBack to article page